DegronMD

Uniprot ID: Q8IV45

Source protein: UNC5C-like protein

Source gene: UNC5CL

Class: DEG_SCF_FBW7_2

Location: 56:61

E3 ligase: FBXW7

DEGRON score: 0.9666

ASA_SCORE: 85.0667

COIL: 0.7758

CONS_SCORE: 0.5537

DSS_SCORE: 0.6356

HELIX: 0.2013

FCONS_SCORE: 1.1491

RIG_SCORE: 0.6762

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T57P	TCGA-OR-A5K9	ACC	TCGA	PTPQLE	DEG_SCF_FBW7_2	0.7031
p.N62K	TCGA-14-1795	GBM	TCGA	PTPQLE	DEG_SCF_FBW7_2	0.3056
p.N62K	DO13114	GBM	ICGC	PTPQLE	DEG_SCF_FBW7_2	0.3056
p.V53M	TCGA-IB-7651	PAAD	TCGA	PTPQLE	DEG_SCF_FBW7_2	0.25
p.V53M	DO46657	PAAD	ICGC	PTPQLE	DEG_SCF_FBW7_2	0.25
p.R66M	TCGA-AP-A051	UCEC	TCGA	PTPQLE	DEG_SCF_FBW7_2	0.1944
p.R66M	DO42673	UCEC	ICGC	PTPQLE	DEG_SCF_FBW7_2	0.1944
p.E51K	TCGA-D3-A51G	SKCM	TCGA	PTPQLE	DEG_SCF_FBW7_2	0.1944
p.E51K	TCGA-EE-A2GU	SKCM	TCGA	PTPQLE	DEG_SCF_FBW7_2	0.1944
p.E51K	DO37639	SKCM	ICGC	PTPQLE	DEG_SCF_FBW7_2	0.1944
p.E51K	DO47700	SKCM	ICGC	PTPQLE	DEG_SCF_FBW7_2	0.1944
p.P70T	DO229034	LICA	ICGC	PTPQLE	DEG_SCF_FBW7_2	0.0833

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV45	UNC5C-like protein	DEG_SCF_FBW7_2	56:61	PTPQLE	FBXW7	0.9666	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons