DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPSDE
Uniprot ID:
Q96RV3
Source protein:
Pecanex-like protein 1
Source gene:
PCNX1
Class:
DEG_SCF_FBW7_2
Location:
470:475
E3 ligase:
FBXW7
DEGRON score:
0.7648
ASA_SCORE:
86.6333
COIL:
0.816
CONS_SCORE:
0.3158
DSS_SCORE:
0.8008
HELIX:
0.1683
FCONS_SCORE:
0.8942
RIG_SCORE:
0.581
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PCNX1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPSDE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96RV3
Pecanex-like protein 1
DEG_SCF_FBW7_2
470:475
PTPSDE
FBXW7
0.7648
More...