DegronMD

Uniprot ID: A8MYV0

Source protein: Doublecortin domain-containing protein 2C

Source gene: DCDC2C

Class: DEG_SCF_FBW7_2

Location: 292:297

E3 ligase: FBXW7

DEGRON score: 0.7847

ASA_SCORE: 85.7167

COIL: 0.76

CONS_SCORE: 0.7493

DSS_SCORE: 0.5875

HELIX: 0.1945

FCONS_SCORE: 1.0215

RIG_SCORE: 0.6457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E297K	SIDM00545	Melanoma	GDSC	PTPSKE	DEG_SCF_FBW7_2	0.7022
p.E297K	Mewo	skin	COSMIC	PTPSKE	DEG_SCF_FBW7_2	0.7022
p.G286V	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PTPSKE	DEG_SCF_FBW7_2	0.1667
p.G286V	CAL-12T	lung	COSMIC	PTPSKE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MYV0	Doublecortin domain-containing protein 2C	DEG_SCF_FBW7_2	292:297	PTPSKE	FBXW7	0.7847	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons