DegronMD - A8MYV0(DCDC2C)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A3V	DO227674	COCA	ICGC	VDTTPAKT	DEG_SCF_FBW7_1	10:17	Mutation blocking phosphorylation signal	0.5833
p.A3V	DO227674	COCA	ICGC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	9:16	Mutation blocking phosphorylation signal	0.6111
p.F6L	DO228555	LICA	ICGC	VDTTPAKT	DEG_SCF_FBW7_1	10:17	Mutation rewiring degron network	0.2222
p.F6L	DO228555	LICA	ICGC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	9:16	Mutation rewiring degron network	0.25
p.F6L	DO228986	LICA	ICGC	VDTTPAKT	DEG_SCF_FBW7_1	10:17	Mutation rewiring degron network	0.2222
p.F6L	DO228986	LICA	ICGC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	9:16	Mutation rewiring degron network	0.25
p.G20V	DO229018	LICA	ICGC	VDTTPAKT	DEG_SCF_FBW7_1	10:17	Mutation rewiring degron network	0.25
p.G20V	DO229018	LICA	ICGC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	9:16	Mutation rewiring degron network	0.2222
p.A4S	DO229028	LICA	ICGC	VDTTPAKT	DEG_SCF_FBW7_1	10:17	Mutation rewiring degron network	0.1667
p.A4S	DO229028	LICA	ICGC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	9:16	Mutation rewiring degron network	0.1944
p.L15I	DO220899	MELA	ICGC	VDTTPAKT	DEG_SCF_FBW7_1	10:17	Mutation altering degron motif	0.7174
p.L15I	DO220899	MELA	ICGC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	9:16	Mutation altering degron motif	0.7174
p.P26L	SIDM01272	Colorectal Carcinoma	GDSC	VDTTPAKT	DEG_SCF_FBW7_1	10:17	Mutation rewiring degron network	0.0833
p.P26L	SIDM01272	Colorectal Carcinoma	GDSC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	9:16	Mutation rewiring degron network	0.0556
p.E297K	SIDM00545	Melanoma	GDSC	PTPSKE	DEG_SCF_FBW7_2	292:297	Mutation altering degron motif	0.7022
p.E297K	Mewo	skin	COSMIC	PTPSKE	DEG_SCF_FBW7_2	292:297	Mutation altering degron motif	0.7022
p.G286V	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PTPSKE	DEG_SCF_FBW7_2	292:297	Mutation rewiring degron network	0.1667
p.G286V	CAL-12T	lung	COSMIC	PTPSKE	DEG_SCF_FBW7_2	292:297	Mutation rewiring degron network	0.1667
p.R22H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	VDTTPAKT	DEG_SCF_FBW7_1	10:17	Mutation rewiring degron network	0.1944
p.R22H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	9:16	Mutation rewiring degron network	0.1667
p.E5D	ACH-000680	Colon/Colorectal Cancer	CCLE	VDTTPAKT	DEG_SCF_FBW7_1	10:17	Mutation rewiring degron network	0.1944
p.E5D	ACH-000680	Colon/Colorectal Cancer	CCLE	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	9:16	Mutation rewiring degron network	0.2222
p.K27M	ACH-000870	Lung Cancer	CCLE	VDTTPAKT	DEG_SCF_FBW7_1	10:17	Mutation rewiring degron network	0.0556

Kaplan plot for DCDC2C in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCDC2C

UniProt ID: A8MYV0

Entrez ID: 728597

Protein name: Doublecortin domain-containing protein 2C

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DCDC2C in