DegronMD

Uniprot ID: A8MYV0

Source protein: Doublecortin domain-containing protein 2C

Source gene: DCDC2C

Class: DEG_SCF_FBW7_1

Location: 10:17

E3 ligase: FBXW7

DEGRON score: 0.8562

ASA_SCORE: 74.725

COIL: 0.7834

CONS_SCORE: 0.7523

DSS_SCORE: 0.4101

HELIX: 0.0098

FCONS_SCORE: 0.9882

RIG_SCORE: 0.7657

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3V	DO227674	COCA	ICGC	VDTTPAKT	DEG_SCF_FBW7_1	0.5833
p.F6L	DO228555	LICA	ICGC	VDTTPAKT	DEG_SCF_FBW7_1	0.2222
p.F6L	DO228986	LICA	ICGC	VDTTPAKT	DEG_SCF_FBW7_1	0.2222
p.G20V	DO229018	LICA	ICGC	VDTTPAKT	DEG_SCF_FBW7_1	0.25
p.A4S	DO229028	LICA	ICGC	VDTTPAKT	DEG_SCF_FBW7_1	0.1667
p.L15I	DO220899	MELA	ICGC	VDTTPAKT	DEG_SCF_FBW7_1	0.7174
p.P26L	SIDM01272	Colorectal Carcinoma	GDSC	VDTTPAKT	DEG_SCF_FBW7_1	0.0833
p.R22H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	VDTTPAKT	DEG_SCF_FBW7_1	0.1944
p.E5D	ACH-000680	Colon/Colorectal Cancer	CCLE	VDTTPAKT	DEG_SCF_FBW7_1	0.1944
p.K27M	ACH-000870	Lung Cancer	CCLE	VDTTPAKT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MYV0	Doublecortin domain-containing protein 2C	DEG_SCF_FBW7_1	10:17	VDTTPAKT	FBXW7	0.8562	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons