DegronMD

Uniprot ID: A8MYV0

Source protein: Doublecortin domain-containing protein 2C

Source gene: DCDC2C

Class: DEG_SCF_SKP2-CKS1_1

Location: 9:16

E3 ligase: SKP2,CSK1

DEGRON score: 0.8847

ASA_SCORE: 81.425

COIL: 0.8994

CONS_SCORE: 0.7517

DSS_SCORE: 0.4407

HELIX: 0.012

FCONS_SCORE: 0.9808

RIG_SCORE: 0.7405

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L15I	DO220899	MELA	ICGC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	0.7174
p.A3V	DO227674	COCA	ICGC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	0.6111
p.F6L	DO228555	LICA	ICGC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	0.25
p.F6L	DO228986	LICA	ICGC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	0.25
p.G20V	DO229018	LICA	ICGC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.E5D	ACH-000680	Colon/Colorectal Cancer	CCLE	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.A4S	DO229028	LICA	ICGC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	0.1944
p.R22H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P26L	SIDM01272	Colorectal Carcinoma	GDSC	PVDTTPAK	DEG_SCF_SKP2-CKS1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MYV0	Doublecortin domain-containing protein 2C	DEG_SCF_SKP2-CKS1_1	9:16	PVDTTPAK	SKP2,CSK1	0.8847	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons