DegronMD

Uniprot ID: Q49A92

Source protein: Uncharacterized protein C8orf34

Source gene: C8orf34

Class: DEG_SCF_FBW7_1

Location: 349:354

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 81.8167

COIL: 0.9277

CONS_SCORE: 0.4326

DSS_SCORE: 0.6986

HELIX: 0.0325

FCONS_SCORE: 1.0931

RIG_SCORE: 0.6001

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D359N	TCGA-33-4589	LUSC	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.1944
p.D341G	TCGA-34-8456	LUSC	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.1111
p.D341G	TCGA-A2-A0YJ	BRCA	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.1111
p.D341G	TCGA-BR-8080	STAD	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.1111
p.E356Q	TCGA-39-5031	LUSC	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.2778
p.E355K	TCGA-63-A5MU	LUSC	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.3056
p.E355K	TCGA-EE-A29A	SKCM	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.3056
p.E356K	TCGA-78-7542	LUAD	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.2778
p.E361D	TCGA-98-8023	LUSC	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.1389
p.D357Y	TCGA-B5-A11E	UCEC	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.25
p.I346T	TCGA-BS-A0TA	UCEC	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.25
p.F343L	TCGA-EB-A41A	SKCM	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.1667
p.E361K	TCGA-EE-A20F	SKCM	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.1389
p.E361K	TCGA-Z2-A8RT	SKCM	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.1389
p.E361K	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.1389
p.E361K	ACH-002215	Lymphoma	CCLE	PTPSVT	DEG_SCF_FBW7_1	0.1389
p.S352Y	TCGA-IB-7651	PAAD	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.6009
p.E356D	TCGA-VQ-AA6J	STAD	TCGA	PTPSVT	DEG_SCF_FBW7_1	0.2778
p.S355L	DO452	BLCA	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.3056
p.S355L	DO37439	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.3056
p.S355L	DO51299	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.3056
p.L359F	DO224989	BRCA	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.1944
p.I344R	DO9002	COAD	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.1944
p.P343Q	DO9812	COAD	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.1667
p.S347Y	DO222798	COCA	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.2778
p.D349E	DO50374	ESAD	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.6758
p.E364Q	DO219062	HNSC	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.0556
p.K351I	DO15182	HNSC	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.7531
p.S341T	DO50800	LIRI	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.1111
p.P353L	DO27723	LUSC	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.7582
p.E363K	DO228376	MALY	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.0833
p.E363K	DO37635	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.0833
p.E350K	DO222875	MELA	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.7022
p.E350K	DO37643	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.7022
p.E350K	DO37429	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.7022
p.E350K	DO48665	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.7022
p.L345R	DO36531	READ	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.2222
p.G361E	DO38081	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.1389
p.S341P	DO47787	STAD	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.1111
p.D357G	DO47769	STAD	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.25
p.L345P	DO42177	UCEC	ICGC	PTPSVT	DEG_SCF_FBW7_1	0.2222
p.P349R	SIDM00582	Pancreatic Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.7512
p.P349R	SIDM01005	Acute Myeloid Leukemia	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.7512
p.P349R	SIDM00282	Colorectal Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.7512
p.P349R	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.7512
p.P349R	SIDM00498	Colorectal Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.7512
p.P349R	SIDM00469	Pancreatic Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.7512
p.P349R	SIDM00591	Oral Cavity Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.7512
p.P349R	SIDM01695	Acute Myeloid Leukemia	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.7512
p.P349R	SIDM00163	Biliary Tract Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.7512
p.P349R	SIDM01588	Endometrial Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.7512
p.P349R	SIDM01451	Pancreatic Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.7512
p.A364V	SIDM00216	Colorectal Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.0556
p.V353I	SIDM01090	Colorectal Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	0.5965
p.V353I	ACH-000943	Colon/Colorectal Cancer	CCLE	PTPSVT	DEG_SCF_FBW7_1	0.5965
p.T350N	ACH-001376	Pancreatic Cancer	CCLE	PTPSVT	DEG_SCF_FBW7_1	0.7055

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPSVT

Degron related mutations and impact score

Drug responses associated with C8orf34 mutations

All proteins holding degron of PTPSVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q49A92	Uncharacterized protein C8orf34	DEG_SCF_FBW7_1	349:354	PTPSVT	FBXW7	0.997	More...