DegronMD - Q49A92(C8orf34)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D359N	TCGA-33-4589	LUSC	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1944
p.D341G	TCGA-34-8456	LUSC	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1111
p.D341G	TCGA-A2-A0YJ	BRCA	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1111
p.D341G	TCGA-BR-8080	STAD	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1111
p.E356Q	TCGA-39-5031	LUSC	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.2778
p.E355K	TCGA-63-A5MU	LUSC	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.3056
p.E355K	TCGA-EE-A29A	SKCM	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.3056
p.E356K	TCGA-78-7542	LUAD	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.2778
p.E361D	TCGA-98-8023	LUSC	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1389
p.A77T	TCGA-A5-A2K3	UCEC	TCGA	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.25
p.A77T	DO232761	PBCA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.25
p.A77T	DO43899	UCEC	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.25
p.Q96K	TCGA-AP-A1DK	UCEC	TCGA	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.1111
p.Q96K	DO42033	UCEC	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.1111
p.D357Y	TCGA-B5-A11E	UCEC	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.25
p.I346T	TCGA-BS-A0TA	UCEC	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.25
p.F343L	TCGA-EB-A41A	SKCM	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1667
p.E361K	TCGA-EE-A20F	SKCM	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1389
p.E361K	TCGA-Z2-A8RT	SKCM	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1389
p.E361K	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1389
p.E361K	ACH-002215	Lymphoma	CCLE	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1389
p.A88T	TCGA-FI-A2D0	UCEC	TCGA	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.6028
p.S352Y	TCGA-IB-7651	PAAD	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.6009
p.E356D	TCGA-VQ-AA6J	STAD	TCGA	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.2778
p.S355L	DO452	BLCA	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.3056
p.S355L	DO37439	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.3056
p.S355L	DO51299	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.3056
p.L359F	DO224989	BRCA	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1944
p.I344R	DO9002	COAD	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1944
p.R81W	DO8447	COAD	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.8634
p.P343Q	DO9812	COAD	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1667
p.S347Y	DO222798	COCA	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.2778
p.R73H	DO222842	COCA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.1389
p.R73H	DO234250	ESAD	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.1389
p.D349E	DO50374	ESAD	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.6758
p.S79T	DO234363	ESAD	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.3056
p.L90V	DO234395	ESAD	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778
p.R82K	DO15455	HNSC	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.7237
p.E364Q	DO219062	HNSC	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.0556
p.K351I	DO15182	HNSC	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7531
p.M87V	DO228299	LICA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.6097
p.L78R	DO228743	LICA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778
p.A92S	DO229019	LICA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2222
p.S98P	DO52239	LIHC	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.0556
p.S341T	DO50800	LIRI	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1111
p.P353L	DO27723	LUSC	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7582
p.D80Y	DO26772	LUSC	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.7325
p.E363K	DO228376	MALY	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.0833
p.E363K	DO37635	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.0833
p.G76E	DO220877	MELA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2222
p.E70K	DO220906	MELA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.0556
p.D85N	DO222731	MELA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.6932
p.D85N	DO220239	SARC	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.6932
p.D85N	DO37415	SKCM	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.6932
p.E350K	DO222875	MELA	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7022
p.E350K	DO37643	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7022
p.E350K	DO37429	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7022
p.E350K	DO48665	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7022
p.L345R	DO36531	READ	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.2222
p.G76R	DO37671	SKCM	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2222
p.S98L	DO37441	SKCM	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.0556
p.G361E	DO38081	SKCM	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1389
p.S341P	DO47787	STAD	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.1111
p.D357G	DO47769	STAD	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.25
p.L345P	DO42177	UCEC	ICGC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.2222
p.P349R	SIDM00582	Pancreatic Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7512
p.P349R	SIDM01005	Acute Myeloid Leukemia	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7512
p.P349R	SIDM00282	Colorectal Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7512
p.P349R	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7512
p.P349R	SIDM00498	Colorectal Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7512
p.P349R	SIDM00469	Pancreatic Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7512
p.P349R	SIDM00591	Oral Cavity Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7512
p.P349R	SIDM01695	Acute Myeloid Leukemia	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7512
p.P349R	SIDM00163	Biliary Tract Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7512
p.P349R	SIDM01588	Endometrial Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7512
p.P349R	SIDM01451	Pancreatic Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7512
p.A364V	SIDM00216	Colorectal Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation rewiring degron network	0.0556
p.V353I	SIDM01090	Colorectal Carcinoma	GDSC	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.5965
p.V353I	ACH-000943	Colon/Colorectal Cancer	CCLE	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.5965
p.A88V	SIDM00789	Colorectal Carcinoma	GDSC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5825
p.R73C	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.1389
p.P86S	SIDM01228	Melanoma	GDSC	SRSHLFPMA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5641
p.T350N	ACH-001376	Pancreatic Cancer	CCLE	PTPSVT	DEG_SCF_FBW7_1	349:354	Mutation altering degron motif	0.7055

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C8orf34

UniProt ID: Q49A92

Entrez ID: 116328

Protein name: Uncharacterized protein C8orf34 (Protein VEST-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C8orf34 in