DegronMD

Uniprot ID: Q49A92

Source protein: Uncharacterized protein C8orf34

Source gene: C8orf34

Class: DEG_APCC_DBOX_1

Location: 80:88

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9992

ASA_SCORE: 77.4889

COIL: 0.7623

CONS_SCORE: 0.6578

DSS_SCORE: 0.5038

HELIX: 0.1681

FCONS_SCORE: 1.2637

RIG_SCORE: 0.6766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A77T	TCGA-A5-A2K3	UCEC	TCGA	SRSHLFPMA	DEG_APCC_DBOX_1	0.25
p.A77T	DO232761	PBCA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.25
p.A77T	DO43899	UCEC	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.25
p.Q96K	TCGA-AP-A1DK	UCEC	TCGA	SRSHLFPMA	DEG_APCC_DBOX_1	0.1111
p.Q96K	DO42033	UCEC	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.1111
p.A88T	TCGA-FI-A2D0	UCEC	TCGA	SRSHLFPMA	DEG_APCC_DBOX_1	0.6028
p.R81W	DO8447	COAD	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.8634
p.R73H	DO222842	COCA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.1389
p.R73H	DO234250	ESAD	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.1389
p.S79T	DO234363	ESAD	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.3056
p.L90V	DO234395	ESAD	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.2778
p.R82K	DO15455	HNSC	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.7237
p.M87V	DO228299	LICA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.6097
p.L78R	DO228743	LICA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.2778
p.A92S	DO229019	LICA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.2222
p.S98P	DO52239	LIHC	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.0556
p.D80Y	DO26772	LUSC	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.7325
p.G76E	DO220877	MELA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.2222
p.E70K	DO220906	MELA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.0556
p.D85N	DO222731	MELA	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.6932
p.D85N	DO220239	SARC	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.6932
p.D85N	DO37415	SKCM	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.6932
p.G76R	DO37671	SKCM	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.2222
p.S98L	DO37441	SKCM	ICGC	SRSHLFPMA	DEG_APCC_DBOX_1	0.0556
p.A88V	SIDM00789	Colorectal Carcinoma	GDSC	SRSHLFPMA	DEG_APCC_DBOX_1	0.5825
p.R73C	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	SRSHLFPMA	DEG_APCC_DBOX_1	0.1389
p.P86S	SIDM01228	Melanoma	GDSC	SRSHLFPMA	DEG_APCC_DBOX_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q49A92	Uncharacterized protein C8orf34	DEG_APCC_DBOX_1	80:88	SRSHLFPMA	APC,CDC20,FZR1	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRSHLFPMA

Degron related mutations and impact score

Drug responses associated with C8orf34 mutations

All proteins holding degron of SRSHLFPMA