DegronMD

Uniprot ID: Q9UEG4

Source protein: Zinc finger protein 629

Source gene: ZNF629

Class: DEG_SCF_FBW7_1

Location: 819:824

E3 ligase: FBXW7

DEGRON score: 0.6845

ASA_SCORE: 71.25

COIL: 0.7335

CONS_SCORE: 0.4142

DSS_SCORE: 0.9084

HELIX: 0.0975

FCONS_SCORE: 1.0028

RIG_SCORE: 0.5507

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G814V	TCGA-78-7148	LUAD	TCGA	PTPTES	DEG_SCF_FBW7_1	0.1944
p.G814V	DO26112	LUAD	ICGC	PTPTES	DEG_SCF_FBW7_1	0.1944
p.S825G	TCGA-A2-A1FX	BRCA	TCGA	PTPTES	DEG_SCF_FBW7_1	0.3056
p.S825G	DO5088	BRCA	ICGC	PTPTES	DEG_SCF_FBW7_1	0.3056
p.G830R	TCGA-B5-A3FA	UCEC	TCGA	PTPTES	DEG_SCF_FBW7_1	0.1667
p.G830R	DO52402	UCEC	ICGC	PTPTES	DEG_SCF_FBW7_1	0.1667
p.G830R	SIDM00122	Breast Carcinoma	GDSC	PTPTES	DEG_SCF_FBW7_1	0.1667
p.G830R	ACH-000288	Breast Cancer	CCLE	PTPTES	DEG_SCF_FBW7_1	0.1667
p.G830R	BT-549	breast	COSMIC	PTPTES	DEG_SCF_FBW7_1	0.1667
p.G816V	TCGA-DQ-5629	HNSC	TCGA	PTPTES	DEG_SCF_FBW7_1	0.25
p.G816V	DO15270	HNSC	ICGC	PTPTES	DEG_SCF_FBW7_1	0.25
p.E823K	TCGA-EY-A215	UCEC	TCGA	PTPTES	DEG_SCF_FBW7_1	0.591
p.E823K	DO42665	UCEC	ICGC	PTPTES	DEG_SCF_FBW7_1	0.591
p.G830E	TCGA-MA-AA42	CESC	TCGA	PTPTES	DEG_SCF_FBW7_1	0.1667
p.G830E	DO219724	CESC	ICGC	PTPTES	DEG_SCF_FBW7_1	0.1667
p.N832T	DO7511	CLLE	ICGC	PTPTES	DEG_SCF_FBW7_1	0.1111
p.S826R	DO229035	LICA	ICGC	PTPTES	DEG_SCF_FBW7_1	0.2778
p.H827L	SIDM00690	Head and Neck Carcinoma	GDSC	PTPTES	DEG_SCF_FBW7_1	0.25
p.H827L	SIDM00529	Breast Carcinoma	GDSC	PTPTES	DEG_SCF_FBW7_1	0.25
p.H827L	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PTPTES	DEG_SCF_FBW7_1	0.25
p.H827L	SIDM00971	Breast Carcinoma	GDSC	PTPTES	DEG_SCF_FBW7_1	0.25
p.H827L	SIDM00844	Burkitt's Lymphoma	GDSC	PTPTES	DEG_SCF_FBW7_1	0.25
p.H827L	SIDM00793	Burkitt's Lymphoma	GDSC	PTPTES	DEG_SCF_FBW7_1	0.25
p.H827L	SIDM01133	Other Solid Cancers	GDSC	PTPTES	DEG_SCF_FBW7_1	0.25
p.H827L	SIDM00068	Colorectal Carcinoma	GDSC	PTPTES	DEG_SCF_FBW7_1	0.25
p.H827L	SIDM01140	Ovarian Carcinoma	GDSC	PTPTES	DEG_SCF_FBW7_1	0.25
p.H827L	SIDM00628	Breast Carcinoma	GDSC	PTPTES	DEG_SCF_FBW7_1	0.25
p.P833L	SIDM00837	Colorectal Carcinoma	GDSC	PTPTES	DEG_SCF_FBW7_1	0.0833
p.P833L	ACH-000958	Colon/Colorectal Cancer	CCLE	PTPTES	DEG_SCF_FBW7_1	0.0833
p.P833L	SW48	large_intestine	COSMIC	PTPTES	DEG_SCF_FBW7_1	0.0833
p.Q812H	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PTPTES	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPTES

Degron related mutations and impact score

Drug responses associated with ZNF629 mutations

All proteins holding degron of PTPTES

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UEG4	Zinc finger protein 629	DEG_SCF_FBW7_1	819:824	PTPTES	FBXW7	0.6845	More...