DegronMD

Uniprot ID: Q92830

Source protein: Histone acetyltransferase KAT2A

Source gene: KAT2A

Class: DEG_SCF_FBW7_1

Location: 26:33

E3 ligase: FBXW7

DEGRON score: 0.8618

ASA_SCORE: 82.325

COIL: 0.939

CONS_SCORE: 0.3094

DSS_SCORE: 0.7711

HELIX: 0.0143

FCONS_SCORE: 0.9864

RIG_SCORE: 0.4746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P16L	DO220884	MELA	ICGC	PTPTPAPS	DEG_SCF_FBW7_1	0.0556
p.P24S	DO222683	MELA	ICGC	PTPTPAPS	DEG_SCF_FBW7_1	0.2778
p.A31T	DO229264	THCA	ICGC	PTPTPAPS	DEG_SCF_FBW7_1	0.6028
p.T43P	ACH-000846	Head and Neck Cancer	CCLE	PTPTPAPS	DEG_SCF_FBW7_1	0.0556
p.T27I	ACH-000972	Endometrial/Uterine Cancer	CCLE	PTPTPAPS	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92830	Histone acetyltransferase KAT2A	DEG_SCF_FBW7_1	26:33	PTPTPAPS	FBXW7	0.8618	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons