DegronMD - Q92830(KAT2A)

FUNCTION: Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, PPARGC1A, PLK4 and TBX5 (PubMed:17301242, PubMed:16753578, PubMed:27796307, PubMed:29174768). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Acts as a negative regulator of gluconeogenesis by mediating acetylation and subsequent inactivation of PPARGC1A (PubMed:16753578, PubMed:23142079). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297). {ECO:0000250|UniProtKB:Q9JHD2, ECO:0000269|PubMed:16753578, ECO:0000269|PubMed:17301242, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:29174768, ECO:0000269|PubMed:29211711, ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837, ECO:0000269|PubMed:31542297}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. {ECO:0000269|PubMed:11384967}. View more >>

GO - Biological processes (BP): alpha-tubulin acetylation [GO:0071929]; cell population proliferation [GO:0008283]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; chromatin remodeling [GO:0006338]; heart development [GO:0007507]; histone acetylation [GO:0016573]; histone deubiquitination [GO:0016578]; histone H3 acetylation [GO:0043966]; histone H3-K14 acetylation [GO:0044154]; histone succinylation [GO:0106077]; internal peptidyl-lysine acetylation [GO:0018393]; intracellular distribution of mitochondria [GO:0048312]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; long-term memory [GO:0007616]; metencephalon development [GO:0022037]; midbrain development [GO:0030901]; monoubiquitinated histone deubiquitination [GO:0035521]; monoubiquitinated histone H2A deubiquitination [GO:0035522]; multicellular organism growth [GO:0035264]; negative regulation of centriole replication [GO:0046600]; neural tube closure [GO:0001843]; peptidyl-lysine glutarylation [GO:0106227]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell projection organization [GO:0031346]; positive regulation of cytokine production [GO:0001819]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of histone acetylation [GO:0035066]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bone development [GO:1903010]; regulation of cartilage development [GO:0061035]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of embryonic development [GO:0045995]; regulation of histone deacetylation [GO:0031063]; regulation of protein stability [GO:0031647]; regulation of regulatory T cell differentiation [GO:0045589]; regulation of RNA splicing [GO:0043484]; regulation of stem cell population maintenance [GO:2000036]; regulation of synaptic plasticity [GO:0048167]; regulation of T cell activation [GO:0050863]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; somitogenesis [GO:0001756]; telencephalon development [GO:0021537] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S410I	TCGA-AP-A1DK	UCEC	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.2778
p.S410I	DO42033	UCEC	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.2778
p.I406V	TCGA-BH-A18G	BRCA	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation altering degron motif	0.5965
p.I406V	DO3686	BRCA	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation altering degron motif	0.5965
p.S418F	TCGA-D3-A8GO	SKCM	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.0556
p.S418F	DO51242	SKCM	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.0556
p.P405T	TCGA-E2-A1LS	BRCA	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation altering degron motif	0.7031
p.P405T	DO3436	BRCA	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation altering degron motif	0.7031
p.A399T	TCGA-EC-A1QX	UCEC	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.2778
p.A399T	DO42592	UCEC	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.2778
p.G413V	TCGA-EE-A29L	SKCM	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.1944
p.G413V	TCGA-EE-A2MG	SKCM	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.1944
p.G413V	DO37835	SKCM	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.1944
p.G413V	DO37421	SKCM	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.1944
p.R392Q	TCGA-FD-A6TH	BLCA	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.0833
p.R392Q	DO49763	BLCA	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.0833
p.G414C	TCGA-NJ-A4YQ	LUAD	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.1667
p.G414C	DO218944	LUAD	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.1667
p.S415R	DO229031	LICA	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.1389
p.P16L	DO220884	MELA	ICGC	PTPTPAPS	DEG_SCF_FBW7_1	26:33	Mutation rewiring degron network	0.0556
p.P24S	DO222683	MELA	ICGC	PTPTPAPS	DEG_SCF_FBW7_1	26:33	Mutation rewiring degron network	0.2778
p.A31T	DO229264	THCA	ICGC	PTPTPAPS	DEG_SCF_FBW7_1	26:33	Mutation altering degron motif	0.6028
p.P402H	SIDM00934	Pancreatic Carcinoma	GDSC	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation altering degron motif	0.6583
p.P402H	ACH-000354	Pancreatic Cancer	CCLE	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation altering degron motif	0.6583
p.P402H	CAPAN-1	pancreas	COSMIC	VPSTPIFS	DEG_SCF_FBW7_1	401:408	Mutation altering degron motif	0.6583
p.T43P	ACH-000846	Head and Neck Cancer	CCLE	PTPTPAPS	DEG_SCF_FBW7_1	26:33	Mutation rewiring degron network	0.0556
p.T27I	ACH-000972	Endometrial/Uterine Cancer	CCLE	PTPTPAPS	DEG_SCF_FBW7_1	26:33	Mutation altering degron motif	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KAT2A

UniProt ID: Q92830

Entrez ID: 2648

Protein name: Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KAT2A in