DegronMD

Uniprot ID: Q92830

Source protein: Histone acetyltransferase KAT2A

Source gene: KAT2A

Class: DEG_SCF_FBW7_1

Location: 401:408

E3 ligase: FBXW7

DEGRON score: 0.9586

ASA_SCORE: 75.575

COIL: 0.8786

CONS_SCORE: 0.3058

DSS_SCORE: 0.4609

HELIX: 0.0219

FCONS_SCORE: 0.9783

RIG_SCORE: 0.7165

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S410I	TCGA-AP-A1DK	UCEC	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	0.2778
p.S410I	DO42033	UCEC	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	0.2778
p.I406V	TCGA-BH-A18G	BRCA	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	0.5965
p.I406V	DO3686	BRCA	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	0.5965
p.S418F	TCGA-D3-A8GO	SKCM	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	0.0556
p.S418F	DO51242	SKCM	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	0.0556
p.P405T	TCGA-E2-A1LS	BRCA	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	0.7031
p.P405T	DO3436	BRCA	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	0.7031
p.A399T	TCGA-EC-A1QX	UCEC	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	0.2778
p.A399T	DO42592	UCEC	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	0.2778
p.G413V	TCGA-EE-A29L	SKCM	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	0.1944
p.G413V	TCGA-EE-A2MG	SKCM	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	0.1944
p.G413V	DO37835	SKCM	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	0.1944
p.G413V	DO37421	SKCM	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	0.1944
p.R392Q	TCGA-FD-A6TH	BLCA	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	0.0833
p.R392Q	DO49763	BLCA	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	0.0833
p.G414C	TCGA-NJ-A4YQ	LUAD	TCGA	VPSTPIFS	DEG_SCF_FBW7_1	0.1667
p.G414C	DO218944	LUAD	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	0.1667
p.S415R	DO229031	LICA	ICGC	VPSTPIFS	DEG_SCF_FBW7_1	0.1389
p.P402H	SIDM00934	Pancreatic Carcinoma	GDSC	VPSTPIFS	DEG_SCF_FBW7_1	0.6583
p.P402H	ACH-000354	Pancreatic Cancer	CCLE	VPSTPIFS	DEG_SCF_FBW7_1	0.6583
p.P402H	CAPAN-1	pancreas	COSMIC	VPSTPIFS	DEG_SCF_FBW7_1	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92830	Histone acetyltransferase KAT2A	DEG_SCF_FBW7_1	401:408	VPSTPIFS	FBXW7	0.9586	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons