DegronMD

Uniprot ID: Q68BL7

Source protein: Olfactomedin-like protein 2A

Source gene: OLFML2A

Class: DEG_SCF_FBW7_1

Location: 369:374

E3 ligase: FBXW7

DEGRON score: 0.9856

ASA_SCORE: 83.3333

COIL: 0.92

CONS_SCORE: 0.4486

DSS_SCORE: 0.8055

HELIX: 0.0403

FCONS_SCORE: 1.084

RIG_SCORE: 0.6869

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A365T	TCGA-AP-A1DK	UCEC	TCGA	PTPTTS	DEG_SCF_FBW7_1	0.2222
p.A365T	DO228963	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.2222
p.A365T	DO228960	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.2222
p.A365T	DO228976	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.2222
p.A365T	DO229036	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.2222
p.A365T	DO229060	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.2222
p.A365T	DO42033	UCEC	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.2222
p.T366P	TCGA-BK-A4ZD	UCEC	TCGA	PTPTTS	DEG_SCF_FBW7_1	0.25
p.T366P	DO48184	UCEC	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.25
p.T361A	DO233885	GACA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.1111
p.A360T	DO228943	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.0833
p.A360T	DO229030	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.0833
p.A360T	DO229052	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.0833
p.A360T	DO229051	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.0833
p.A360T	DO229053	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.0833
p.A360T	DO229063	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.0833
p.T364I	DO228944	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.1944
p.T364I	DO229060	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.1944
p.P369T	DO229030	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.7031
p.P369T	DO229056	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.7031
p.P369T	DO229057	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.7031
p.T361I	DO229050	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.1111
p.T366I	DO229050	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.25
p.T370A	DO222595	MELA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.7139
p.T367P	DO229221	THCA	ICGC	PTPTTS	DEG_SCF_FBW7_1	0.2778
p.T364A	ACH-000948	Gastric Cancer	CCLE	PTPTTS	DEG_SCF_FBW7_1	0.1944
p.Y361N	IA-LM	lung	COSMIC	PTPTTS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68BL7	Olfactomedin-like protein 2A	DEG_SCF_FBW7_1	369:374	PTPTTS	FBXW7	0.9856	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons