DegronMD - Q68BL7(OLFML2A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K192M	TCGA-78-7146	LUAD	TCGA	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation substituting flanking lysine	0.3333
p.K192M	DO23717	LUAD	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation substituting flanking lysine	0.3333
p.A212T	TCGA-AP-A1DK	UCEC	TCGA	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.1111
p.A212T	DO42033	UCEC	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.1111
p.A365T	TCGA-AP-A1DK	UCEC	TCGA	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2222
p.A365T	DO228963	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2222
p.A365T	DO228960	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2222
p.A365T	DO228976	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2222
p.A365T	DO229036	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2222
p.A365T	DO229060	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2222
p.A365T	DO42033	UCEC	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2222
p.R197H	TCGA-BK-A26L	UCEC	TCGA	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.8244
p.R197H	DO41355	UCEC	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.8244
p.R197H	SIDM01117	Small Cell Lung Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.8244
p.R197H	SIDM00690	Head and Neck Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.8244
p.R197H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.8244
p.R197H	SIDM01147	Gastric Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.8244
p.T366P	TCGA-BK-A4ZD	UCEC	TCGA	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.25
p.T366P	DO48184	UCEC	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.25
p.K193R	TCGA-VQ-A8PB	STAD	TCGA	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation substituting flanking lysine	0.3611
p.K193R	DO51766	STAD	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation substituting flanking lysine	0.3611
p.T361A	DO233885	GACA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1111
p.A208T	DO229480	LAML	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM00074	Burkitt's Lymphoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM00352	Ovarian Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM00555	Glioblastoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM00238	Ovarian Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM00580	Acute Myeloid Leukemia	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM00241	Breast Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM01257	Hepatocellular Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM01335	Kidney Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM01578	Bladder Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM00062	Hepatocellular Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM01336	Glioblastoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM00170	Head and Neck Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM01575	Plasma Cell Myeloma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM01448	Head and Neck Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM01782	Oral Cavity Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM01774	Pancreatic Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM01473	Plasma Cell Myeloma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM01451	Pancreatic Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM01343	Gastric Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A208T	SIDM00497	Colorectal Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2222
p.A360T	DO228943	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.0833
p.A360T	DO229030	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.0833
p.A360T	DO229052	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.0833
p.A360T	DO229051	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.0833
p.A360T	DO229053	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.0833
p.A360T	DO229063	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.0833
p.T364I	DO228944	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1944
p.T364I	DO229060	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1944
p.G190V	DO229026	LICA	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.1667
p.P369T	DO229030	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.7031
p.P369T	DO229056	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.7031
p.P369T	DO229057	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.7031
p.T361I	DO229050	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1111
p.T366I	DO229050	LICA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.25
p.K205R	DO230934	LUSC	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.3056
p.K205R	DO224581	LUSC	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.3056
p.T370A	DO222595	MELA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.7139
p.A186V	DO46340	OV	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.0556
p.A207V	DO229211	THCA	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.25
p.A207V	SIDM00216	Colorectal Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.25
p.A207V	ACH-000989	Colon/Colorectal Cancer	CCLE	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.25
p.T367P	DO229221	THCA	ICGC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2778
p.K205T	SIDM00434	Plasma Cell Myeloma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.3056
p.K205T	SIDM01020	Plasma Cell Myeloma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.3056
p.K205T	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.3056
p.K205T	SIDM00273	Glioblastoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.3056
p.K205T	SIDM01368	Gastric Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.3056
p.K205T	GI-1	central nervous system	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.3056
p.K205T	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.3056
p.K205T	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.3056
p.K205T	PC-3_[JPC-3]	lung	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.3056
p.A209T	SIDM00608	Plasma Cell Myeloma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.1944
p.A209T	SIDM00871	Non-Cancerous	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.1944
p.A209T	SIDM00872	Breast Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.1944
p.G199C	SIDM00819	Kidney Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.6489
p.G199C	ACH-002189	Kidney Cancer	CCLE	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.6489
p.G199C	RCC-FG2	kidney	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.6489
p.T364A	ACH-000948	Gastric Cancer	CCLE	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1944
p.Y361N	IA-LM	lung	COSMIC	PTPTTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1111
p.R199H	SBC-1	lung	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.8244
p.D207N	NCI-H187	lung	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OLFML2A

UniProt ID: Q68BL7

Entrez ID: 169611

Protein name: Olfactomedin-like protein 2A (Photomedin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OLFML2A in