DegronMD

Uniprot ID: Q68BL7

Source protein: Olfactomedin-like protein 2A

Source gene: OLFML2A

Class: DEG_APCC_DBOX_1

Location: 196:204

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7713

ASA_SCORE: 89.2444

COIL: 0.4337

CONS_SCORE: 0.6362

DSS_SCORE: 0.2714

HELIX: 0.5424

FCONS_SCORE: 1.236

RIG_SCORE: 0.8062

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K192M	TCGA-78-7146	LUAD	TCGA	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3333
p.K192M	DO23717	LUAD	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3333
p.A212T	TCGA-AP-A1DK	UCEC	TCGA	SRLGLQLLQ	DEG_APCC_DBOX_1	0.1111
p.A212T	DO42033	UCEC	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.1111
p.R197H	TCGA-BK-A26L	UCEC	TCGA	SRLGLQLLQ	DEG_APCC_DBOX_1	0.8244
p.R197H	DO41355	UCEC	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.8244
p.R197H	SIDM01117	Small Cell Lung Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.8244
p.R197H	SIDM00690	Head and Neck Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.8244
p.R197H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.8244
p.R197H	SIDM01147	Gastric Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.8244
p.K193R	TCGA-VQ-A8PB	STAD	TCGA	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3611
p.K193R	DO51766	STAD	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3611
p.A208T	DO229480	LAML	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM00074	Burkitt's Lymphoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM00352	Ovarian Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM00555	Glioblastoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM00238	Ovarian Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM00580	Acute Myeloid Leukemia	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM00241	Breast Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM01257	Hepatocellular Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM01335	Kidney Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM01578	Bladder Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM00062	Hepatocellular Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM01336	Glioblastoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM00170	Head and Neck Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM01575	Plasma Cell Myeloma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM01448	Head and Neck Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM01782	Oral Cavity Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM01774	Pancreatic Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM01473	Plasma Cell Myeloma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM01451	Pancreatic Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM01343	Gastric Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.A208T	SIDM00497	Colorectal Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.2222
p.G190V	DO229026	LICA	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.1667
p.K205R	DO230934	LUSC	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3056
p.K205R	DO224581	LUSC	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3056
p.A186V	DO46340	OV	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.0556
p.A207V	DO229211	THCA	ICGC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.25
p.A207V	SIDM00216	Colorectal Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.25
p.A207V	ACH-000989	Colon/Colorectal Cancer	CCLE	SRLGLQLLQ	DEG_APCC_DBOX_1	0.25
p.K205T	SIDM00434	Plasma Cell Myeloma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3056
p.K205T	SIDM01020	Plasma Cell Myeloma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3056
p.K205T	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3056
p.K205T	SIDM00273	Glioblastoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3056
p.K205T	SIDM01368	Gastric Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3056
p.K205T	GI-1	central_nervous_system	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3056
p.K205T	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3056
p.K205T	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3056
p.K205T	PC-3_[JPC-3]	lung	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.3056
p.A209T	SIDM00608	Plasma Cell Myeloma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.1944
p.A209T	SIDM00871	Non-Cancerous	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.1944
p.A209T	SIDM00872	Breast Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.1944
p.G199C	SIDM00819	Kidney Carcinoma	GDSC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.6489
p.G199C	ACH-002189	Kidney Cancer	CCLE	SRLGLQLLQ	DEG_APCC_DBOX_1	0.6489
p.G199C	RCC-FG2	kidney	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.6489
p.R199H	SBC-1	lung	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.8244
p.D207N	NCI-H187	lung	COSMIC	SRLGLQLLQ	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRLGLQLLQ

Degron related mutations and impact score

Drug responses associated with OLFML2A mutations

All proteins holding degron of SRLGLQLLQ

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68BL7	Olfactomedin-like protein 2A	DEG_APCC_DBOX_1	196:204	SRLGLQLLQ	APC,CDC20,FZR1	0.7713	More...