DegronMD

Uniprot ID: Q9BYG3

Source protein: MKI67 FHA domain-interacting nucleolar phosphoprotein

Source gene: NIFK

Class: DEG_SCF_FBW7_1

Location: 233:238

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 82.3333

COIL: 0.9438

CONS_SCORE: 0.3029

DSS_SCORE: 0.5737

HELIX: 0.0245

FCONS_SCORE: 1.0116

RIG_SCORE: 0.7128

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T234S	SIDM00523	Small Cell Lung Carcinoma	GDSC	PTPVCT	DEG_SCF_FBW7_1	0.8227
p.S247C	SIDM00491	Thyroid Gland Carcinoma	GDSC	PTPVCT	DEG_SCF_FBW7_1	0.5278
p.S247C	ASH-3	thyroid	COSMIC	PTPVCT	DEG_SCF_FBW7_1	0.5278
p.G232D	TCGA-BR-4184	STAD	TCGA	PTPVCT	DEG_SCF_FBW7_1	0.3056
p.R245Q	SIDM01398	Melanoma	GDSC	PTPVCT	DEG_SCF_FBW7_1	0.1389

Showing 1 to 5 of 5 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYG3	MKI67 FHA domain-interacting nucleolar phosphoprotein	DEG_SCF_FBW7_1	233:238	PTPVCT	FBXW7	0.9991	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons