DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPVCT
Uniprot ID:
Q9BYG3
Source protein:
MKI67 FHA domain-interacting nucleolar phosphoprotein
Source gene:
NIFK
Class:
DEG_SCF_FBW7_1
Location:
233:238
E3 ligase:
FBXW7
DEGRON score:
0.9991
ASA_SCORE:
82.3333
COIL:
0.9438
CONS_SCORE:
0.3029
DSS_SCORE:
0.5737
HELIX:
0.0245
FCONS_SCORE:
1.0116
RIG_SCORE:
0.7128
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G232D
TCGA-BR-4184
STAD
TCGA
PTPVCT
DEG_SCF_FBW7_1
0.3056
p.S247C
SIDM00491
Thyroid Gland Carcinoma
GDSC
PTPVCT
DEG_SCF_FBW7_1
0.5278
p.S247C
ASH-3
thyroid
COSMIC
PTPVCT
DEG_SCF_FBW7_1
0.5278
p.T234S
SIDM00523
Small Cell Lung Carcinoma
GDSC
PTPVCT
DEG_SCF_FBW7_1
0.8227
p.R245Q
SIDM01398
Melanoma
GDSC
PTPVCT
DEG_SCF_FBW7_1
0.1389
Drug responses associated with NIFK mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPVCT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BYG3
MKI67 FHA domain-interacting nucleolar phosphoprotein
DEG_SCF_FBW7_1
233:238
PTPVCT
FBXW7
0.9991
More...