DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 12980:12987

E3 ligase: FBXW7

DEGRON score: 0.7736

ASA_SCORE: 74.6

COIL: 0.913

CONS_SCORE: 0

DSS_SCORE: 0.5629

HELIX: 0.0212

FCONS_SCORE: 0

RIG_SCORE: 0.6141

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N12970S	TCGA-49-AARE	LUAD	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.0556
p.N12970S	DO218922	LUAD	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.0556
p.R12975W	TCGA-96-A4JK	LUSC	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.1944
p.R12975W	DO45442	LUSC	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.1944
p.R12975W	SIDM00632	Non-Cancerous	GDSC	PTSTPGTS	DEG_SCF_FBW7_1	0.1944
p.R12975W	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	PTSTPGTS	DEG_SCF_FBW7_1	0.1944
p.S12977F	TCGA-BR-8484	STAD	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.25
p.S12977F	DO222837	MELA	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.25
p.S12977F	DO48024	STAD	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.25
p.R12975Q	TCGA-BR-A4CQ	STAD	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.1944
p.R12975Q	DO47861	STAD	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.1944
p.L12991R	TCGA-CG-5724	STAD	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.2222
p.L12991R	DO38847	STAD	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.2222
p.P12980H	TCGA-CQ-5330	HNSC	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.7694
p.P12980H	DO16037	HNSC	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.7694
p.F12972L	TCGA-CQ-A4CD	HNSC	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.1111
p.F12972L	DO49038	HNSC	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.1111
p.T12993S	TCGA-CV-7248	HNSC	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.1667
p.T12993S	DO14806	HNSC	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.1667
p.P12997L	TCGA-EE-A2GO	SKCM	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.0556
p.P12997L	DO37823	SKCM	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.0556
p.G12992V	TCGA-EE-A2GT	SKCM	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.1944
p.G12992V	DO37946	SKCM	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.1944
p.G12995E	TCGA-EE-A2MC	SKCM	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.1111
p.G12995E	DO228825	LICA	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.1111
p.G12995E	DO222426	MELA	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.1111
p.G12995E	DO37559	SKCM	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.1111
p.G12995E	SIDM00140	Melanoma	GDSC	PTSTPGTS	DEG_SCF_FBW7_1	0.1111
p.G12995E	ACH-000968	Skin Cancer	CCLE	PTSTPGTS	DEG_SCF_FBW7_1	0.1111
p.G12995E	COLO-792	skin	COSMIC	PTSTPGTS	DEG_SCF_FBW7_1	0.1111
p.G12995W	TCGA-EI-6917	READ	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.1111
p.G12995W	DO36881	READ	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.1111
p.P12984S	TCGA-VS-A9U5	CESC	TCGA	PTSTPGTS	DEG_SCF_FBW7_1	0.6752
p.P12984S	DO51641	CESC	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.6752
p.P12984S	SIDM01198	Burkitt's Lymphoma	GDSC	PTSTPGTS	DEG_SCF_FBW7_1	0.6752
p.P12984S	ACH-000567	Lymphoma	CCLE	PTSTPGTS	DEG_SCF_FBW7_1	0.6752
p.P12984S	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	PTSTPGTS	DEG_SCF_FBW7_1	0.6752
p.T12983N	DO234269	ESAD	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.7055
p.L12991F	DO228202	LICA	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.2222
p.T12993I	DO229177	LMS	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.1667
p.D12990N	DO218884	SKCA	ICGC	PTSTPGTS	DEG_SCF_FBW7_1	0.25
p.P12984L	SIDM00931	Thyroid Gland Carcinoma	GDSC	PTSTPGTS	DEG_SCF_FBW7_1	0.7582
p.P12984L	SIDM00861	Ovarian Carcinoma	GDSC	PTSTPGTS	DEG_SCF_FBW7_1	0.7582
p.P12984L	ACH-000174	Thyroid Cancer	CCLE	PTSTPGTS	DEG_SCF_FBW7_1	0.7582
p.P12984L	ACH-000906	Ovarian Cancer	CCLE	PTSTPGTS	DEG_SCF_FBW7_1	0.7582
p.P12984L	CAL-62	thyroid	COSMIC	PTSTPGTS	DEG_SCF_FBW7_1	0.7582
p.P12984L	ES-2	ovary	COSMIC	PTSTPGTS	DEG_SCF_FBW7_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSTPGTS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PTSTPGTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	12980:12987	PTSTPGTS	FBXW7	0.7736	More...