DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 1674:1680

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 75.7143

COIL: 0.9247

CONS_SCORE: 0.3932

DSS_SCORE: 0.7298

HELIX: 0.02

FCONS_SCORE: 1.0798

RIG_SCORE: 0.5995

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1675K	TCGA-56-8083	LUSC	TCGA	PTTPAGS	DEG_SCF_FBW7_1	0.6195
p.T1675M	TCGA-A6-5657	COAD	TCGA	PTTPAGS	DEG_SCF_FBW7_1	0.6312
p.T1676M	TCGA-AX-A1C4	UCEC	TCGA	PTTPAGS	DEG_SCF_FBW7_1	0.7423
p.G1667S	TCGA-EE-A2MN	SKCM	TCGA	PTTPAGS	DEG_SCF_FBW7_1	0.1389
p.T1678M	DO10459	COAD	ICGC	PTTPAGS	DEG_SCF_FBW7_1	0.7423
p.T1673N	DO222755	COCA	ICGC	PTTPAGS	DEG_SCF_FBW7_1	0.3056
p.T1679M	DO50812	LICA	ICGC	PTTPAGS	DEG_SCF_FBW7_1	0.7423
p.T1679M	DO42480	UCEC	ICGC	PTTPAGS	DEG_SCF_FBW7_1	0.7423
p.T1666R	DO27747	LUSC	ICGC	PTTPAGS	DEG_SCF_FBW7_1	0.1111
p.T1678K	DO223723	LUSC	ICGC	PTTPAGS	DEG_SCF_FBW7_1	0.7306
p.G1670S	DO222438	MELA	ICGC	PTTPAGS	DEG_SCF_FBW7_1	0.2222
p.G1670S	DO37423	SKCM	ICGC	PTTPAGS	DEG_SCF_FBW7_1	0.2222
p.R1664I	DO41572	UCEC	ICGC	PTTPAGS	DEG_SCF_FBW7_1	0.0556
p.L1666I	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PTTPAGS	DEG_SCF_FBW7_1	0.1111
p.L1666I	ACH-000995	Leukemia	CCLE	PTTPAGS	DEG_SCF_FBW7_1	0.1111
p.L1666I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPAGS	DEG_SCF_FBW7_1	0.1111
p.A1678V	SIDM00643	Non-Cancerous	GDSC	PTTPAGS	DEG_SCF_FBW7_1	0.5825
p.A1678V	ACH-000327	Lung Cancer	CCLE	PTTPAGS	DEG_SCF_FBW7_1	0.5825
p.A1678V	ACH-002363	Non-Cancerous	CCLE	PTTPAGS	DEG_SCF_FBW7_1	0.5825
p.S1664N	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PTTPAGS	DEG_SCF_FBW7_1	0.0556
p.S1664N	ACH-000960	Leukemia	CCLE	PTTPAGS	DEG_SCF_FBW7_1	0.0556
p.S1664N	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPAGS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	1674:1680	PTTPAGS	FBXW7	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons