DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SCF_FBW7_1

Location: 1325:1331

E3 ligase: FBXW7

DEGRON score: 0.6478

ASA_SCORE: 92.5286

COIL: 0.927

CONS_SCORE: 0.3842

DSS_SCORE: 0.7271

HELIX: 0.0574

FCONS_SCORE: 0.9731

RIG_SCORE: 0.588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1340P	TCGA-AA-3510	COAD	TCGA	PTTPDPS	DEG_SCF_FBW7_1	0.0833
p.S1340P	DO7783	COAD	ICGC	PTTPDPS	DEG_SCF_FBW7_1	0.0833
p.S1340P	ACH-001518	Endometrial/Uterine Cancer	CCLE	PTTPDPS	DEG_SCF_FBW7_1	0.0833
p.V1335F	DO229006	LICA	ICGC	PTTPDPS	DEG_SCF_FBW7_1	0.2222
p.P1325T	DO50940	LICA	ICGC	PTTPDPS	DEG_SCF_FBW7_1	0.7031
p.P1325T	DO231760	LINC	ICGC	PTTPDPS	DEG_SCF_FBW7_1	0.7031
p.P1328L	DO222887	MELA	ICGC	PTTPDPS	DEG_SCF_FBW7_1	0.7582
p.P1328L	DO41199	UCEC	ICGC	PTTPDPS	DEG_SCF_FBW7_1	0.7582
p.I1336V	SIDM00745	Non-Small Cell Lung Carcinoma	GDSC	PTTPDPS	DEG_SCF_FBW7_1	0.1944
p.I1336V	ACH-000035	Lung Cancer	CCLE	PTTPDPS	DEG_SCF_FBW7_1	0.1944
p.I1336V	NCI-H1650	lung	COSMIC	PTTPDPS	DEG_SCF_FBW7_1	0.1944
p.T1321M	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PTTPDPS	DEG_SCF_FBW7_1	0.2222
p.T1321M	ACH-000918	Leukemia	CCLE	PTTPDPS	DEG_SCF_FBW7_1	0.2222
p.T1321M	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPDPS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1325:1331	PTTPDPS	FBXW7	0.6478	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons