DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_2

Location: 1755:1761

E3 ligase: FBXW7

DEGRON score: 0.9109

ASA_SCORE: 93.9286

COIL: 0.8976

CONS_SCORE: 0

DSS_SCORE: 0.4754

HELIX: 0.0297

FCONS_SCORE: 0

RIG_SCORE: 0.7365

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1758T	TCGA-A2-A0T0	BRCA	TCGA	PTTPDVE	DEG_SCF_FBW7_2	0.7031
p.P1758T	DO4122	BRCA	ICGC	PTTPDVE	DEG_SCF_FBW7_2	0.7031
p.F1768L	TCGA-BR-7959	STAD	TCGA	PTTPDVE	DEG_SCF_FBW7_2	0.1389
p.F1768L	DO38408	STAD	ICGC	PTTPDVE	DEG_SCF_FBW7_2	0.1389
p.D1759V	TCGA-DD-AADU	LIHC	TCGA	PTTPDVE	DEG_SCF_FBW7_2	0.6674
p.D1759V	DO52248	LIHC	ICGC	PTTPDVE	DEG_SCF_FBW7_2	0.6674
p.E1761K	TCGA-F5-6814	READ	TCGA	PTTPDVE	DEG_SCF_FBW7_2	0.7022
p.E1761K	DO36556	READ	ICGC	PTTPDVE	DEG_SCF_FBW7_2	0.7022
p.F1762C	TCGA-L5-A4OT	ESCA	TCGA	PTTPDVE	DEG_SCF_FBW7_2	0.3056
p.P1755S	TCGA-QQ-A5VD	SARC	TCGA	PTTPDVE	DEG_SCF_FBW7_2	0.6752
p.P1755S	DO220252	SARC	ICGC	PTTPDVE	DEG_SCF_FBW7_2	0.6752
p.P1758S	TCGA-VS-A9UC	CESC	TCGA	PTTPDVE	DEG_SCF_FBW7_2	0.6752
p.P1758S	DO219732	CESC	ICGC	PTTPDVE	DEG_SCF_FBW7_2	0.6752
p.P1758S	ACH-001647	Leukemia	CCLE	PTTPDVE	DEG_SCF_FBW7_2	0.6752
p.S1746R	DO223552	CLLE	ICGC	PTTPDVE	DEG_SCF_FBW7_2	0.0833
p.S1748R	DO233168	GACA	ICGC	PTTPDVE	DEG_SCF_FBW7_2	0.1389
p.T1767K	DO228976	LICA	ICGC	PTTPDVE	DEG_SCF_FBW7_2	0.1667
p.G1764A	SIDM00084	Glioblastoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.25
p.G1764A	SIDM00148	Breast Carcinoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.25
p.G1764A	ACH-000019	Breast Cancer	CCLE	PTTPDVE	DEG_SCF_FBW7_2	0.25
p.G1764A	ACH-000028	Breast Cancer	CCLE	PTTPDVE	DEG_SCF_FBW7_2	0.25
p.G1764A	ACH-000376	Brain Cancer	CCLE	PTTPDVE	DEG_SCF_FBW7_2	0.25
p.G1764A	MCF7	breast	COSMIC	PTTPDVE	DEG_SCF_FBW7_2	0.25
p.G1764A	SF295	central_nervous_system	COSMIC	PTTPDVE	DEG_SCF_FBW7_2	0.25
p.E1761G	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM00454	Rhabdomyosarcoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM00654	Small Cell Lung Carcinoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM00210	Ovarian Carcinoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM01112	Osteosarcoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM00650	Small Cell Lung Carcinoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM00854	Burkitt's Lymphoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM00849	Kidney Carcinoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM00863	Burkitt's Lymphoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM01681	Non-Cancerous	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM00673	Breast Carcinoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM00808	Burkitt's Lymphoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM00760	Small Cell Lung Carcinoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM01318	Hepatocellular Carcinoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.E1761G	SIDM01254	Burkitt's Lymphoma	GDSC	PTTPDVE	DEG_SCF_FBW7_2	0.7199
p.K1771T	ACH-001130	Lymphoma	CCLE	PTTPDVE	DEG_SCF_FBW7_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTPDVE

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PTTPDVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_2	1755:1761	PTTPDVE	FBXW7	0.9109	More...