DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SCF_FBW7_1

Location: 1176:1182

E3 ligase: FBXW7

DEGRON score: 0.9132

ASA_SCORE: 99.3429

COIL: 0.9507

CONS_SCORE: 0.3034

DSS_SCORE: 0.7372

HELIX: 0.0106

FCONS_SCORE: 0.992

RIG_SCORE: 0.5793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1186Y	TCGA-AC-A23H	BRCA	TCGA	PTTPHPT	DEG_SCF_FBW7_1	0.2222
p.H1186Y	DO2401	BRCA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.2222
p.H1186Q	DO222790	COCA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.2222
p.H1186Q	DO229005	COCA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.2222
p.H1186Q	DO228947	LICA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.2222
p.H1186Q	DO229047	LICA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.2222
p.T1183M	DO229005	COCA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.3056
p.T1183M	DO228941	LICA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.3056
p.T1183M	DO228947	LICA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.3056
p.T1183M	DO229047	LICA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.3056
p.T1182S	DO229005	COCA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.6005
p.T1182S	DO228941	LICA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.6005
p.T1182S	DO228947	LICA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.6005
p.T1182S	DO229047	LICA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.6005
p.I1190M	DO46733	PACA	ICGC	PTTPHPT	DEG_SCF_FBW7_1	0.1111
p.F1175Y	SIDM00286	Neuroblastoma	GDSC	PTTPHPT	DEG_SCF_FBW7_1	0.3056
p.F1175Y	SIDM00832	Colorectal Carcinoma	GDSC	PTTPHPT	DEG_SCF_FBW7_1	0.3056
p.F1175Y	SIDM01099	Neuroblastoma	GDSC	PTTPHPT	DEG_SCF_FBW7_1	0.3056
p.F1175Y	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PTTPHPT	DEG_SCF_FBW7_1	0.3056
p.F1175Y	SIDM01680	Non-Cancerous	GDSC	PTTPHPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1176:1182	PTTPHPT	FBXW7	0.9132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons