DegronMD

Uniprot ID: Q8NFU4

Source protein: Follicular dendritic cell secreted peptide

Source gene: FDCSP

Class: DEG_SCF_FBW7_1

Location: 77:83

E3 ligase: FBXW7

DEGRON score: 0.704

ASA_SCORE: 88.3143

COIL: 0.9531

CONS_SCORE: 0.8732

DSS_SCORE: 0.7987

HELIX: 0.0259

FCONS_SCORE: 1.0069

RIG_SCORE: 0.6518

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P73L	TCGA-5N-A9KI	BLCA	TCGA	PTTPLPS	DEG_SCF_FBW7_1	0.2222
p.P73L	DO223513	BLCA	ICGC	PTTPLPS	DEG_SCF_FBW7_1	0.2222
p.E84K	TCGA-AM-5821	COAD	TCGA	PTTPLPS	DEG_SCF_FBW7_1	0.3056
p.E84K	DO8240	COAD	ICGC	PTTPLPS	DEG_SCF_FBW7_1	0.3056
p.E84K	DO218547	GACA	ICGC	PTTPLPS	DEG_SCF_FBW7_1	0.3056
p.P71L	TCGA-CR-7368	HNSC	TCGA	PTTPLPS	DEG_SCF_FBW7_1	0.1667
p.P71L	DO14167	HNSC	ICGC	PTTPLPS	DEG_SCF_FBW7_1	0.1667
p.E74K	TCGA-DF-A2KU	UCEC	TCGA	PTTPLPS	DEG_SCF_FBW7_1	0.25
p.E74K	DO223286	UCEC	ICGC	PTTPLPS	DEG_SCF_FBW7_1	0.25
p.K85N	DO228985	LICA	ICGC	PTTPLPS	DEG_SCF_FBW7_1	0.2778
p.P69A	DO222355	LICA	ICGC	PTTPLPS	DEG_SCF_FBW7_1	0.1111
p.P69S	SIDM00336	Melanoma	GDSC	PTTPLPS	DEG_SCF_FBW7_1	0.1111
p.P69S	ACH-000881	Skin Cancer	CCLE	PTTPLPS	DEG_SCF_FBW7_1	0.1111
p.P69S	MEL-JUSO	skin	COSMIC	PTTPLPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFU4	Follicular dendritic cell secreted peptide	DEG_SCF_FBW7_1	77:83	PTTPLPS	FBXW7	0.704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons