DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PTTTPHST
Uniprot ID:
A1L4H1
Source protein:
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
Source gene:
SSC5D
Class:
DEG_SCF_FBW7_1
Location:
1230:1237
E3 ligase:
FBXW7
DEGRON score:
0.8555
ASA_SCORE:
98.4
COIL:
0.9615
CONS_SCORE:
0.3041
DSS_SCORE:
0.7901
HELIX:
0.0131
FCONS_SCORE:
0.902
RIG_SCORE:
0.5711
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1236P
DO229470
SKCA
ICGC
PTTTPHST
DEG_SCF_FBW7_1
0.5641
p.S1236P
DO229232
THCA
ICGC
PTTTPHST
DEG_SCF_FBW7_1
0.5641
Drug responses associated with SSC5D mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTTTPHST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A1L4H1
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
DEG_SCF_FBW7_1
1230:1237
PTTTPHST
FBXW7
0.8555
More...