DegronMD

Uniprot ID: Q15942

Source protein: Zyxin

Source gene: ZYX

Class: DEG_SCF_FBW7_1

Location: 176:183

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 88.8875

COIL: 0.9614

CONS_SCORE: 0.3396

DSS_SCORE: 0.5239

HELIX: 0.0173

FCONS_SCORE: 1.0007

RIG_SCORE: 0.6491

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R167L	TCGA-55-7227	LUAD	TCGA	PVATPFSS	DEG_SCF_FBW7_1	0.0833
p.R167L	DO24050	LUAD	ICGC	PVATPFSS	DEG_SCF_FBW7_1	0.0833
p.G192W	TCGA-EE-A3AA	SKCM	TCGA	PVATPFSS	DEG_SCF_FBW7_1	0.0833
p.G192W	DO37571	SKCM	ICGC	PVATPFSS	DEG_SCF_FBW7_1	0.0833
p.A191V	TCGA-ER-A19E	SKCM	TCGA	PVATPFSS	DEG_SCF_FBW7_1	0.1111
p.A191V	DO47542	SKCM	ICGC	PVATPFSS	DEG_SCF_FBW7_1	0.1111
p.P180T	TCGA-F5-6814	READ	TCGA	PVATPFSS	DEG_SCF_FBW7_1	0.7031
p.P180T	DO36556	READ	ICGC	PVATPFSS	DEG_SCF_FBW7_1	0.7031
p.S186N	TCGA-FI-A2D0	UCEC	TCGA	PVATPFSS	DEG_SCF_FBW7_1	0.25
p.S186N	DO233784	GACA	ICGC	PVATPFSS	DEG_SCF_FBW7_1	0.25
p.S186N	DO43891	UCEC	ICGC	PVATPFSS	DEG_SCF_FBW7_1	0.25
p.S182N	TCGA-HU-8602	STAD	TCGA	PVATPFSS	DEG_SCF_FBW7_1	0.5958
p.S182N	DO47829	STAD	ICGC	PVATPFSS	DEG_SCF_FBW7_1	0.5958
p.S186I	DO232224	PBCA	ICGC	PVATPFSS	DEG_SCF_FBW7_1	0.25
p.G192R	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	PVATPFSS	DEG_SCF_FBW7_1	0.0833
p.G192R	SW900	lung	COSMIC	PVATPFSS	DEG_SCF_FBW7_1	0.0833
p.P174A	SIDM01608	Endometrial Carcinoma	GDSC	PVATPFSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15942	Zyxin	DEG_SCF_FBW7_1	176:183	PVATPFSS	FBXW7	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons