DegronMD - Q15942(ZYX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P260L	TCGA-22-5473	LUSC	TCGA	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation rewiring degron network	0.1111
p.P260L	DO26467	LUSC	ICGC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation rewiring degron network	0.1111
p.S259Y	TCGA-2Y-A9HA	LIHC	TCGA	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation blocking phosphorylation signal	0.5278
p.S259Y	DO219539	LIHC	ICGC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation blocking phosphorylation signal	0.5278
p.R167L	TCGA-55-7227	LUAD	TCGA	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.0833
p.R167L	DO24050	LUAD	ICGC	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.0833
p.P271H	TCGA-AG-A002	READ	TCGA	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation altering degron motif	0.7694
p.P260T	TCGA-AP-A051	UCEC	TCGA	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation rewiring degron network	0.1111
p.P260T	DO42673	UCEC	ICGC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation rewiring degron network	0.1111
p.F273V	TCGA-BF-A1Q0	SKCM	TCGA	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation altering degron motif	0.5957
p.F273V	DO47374	SKCM	ICGC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation altering degron motif	0.5957
p.S258A	TCGA-D1-A17B	UCEC	TCGA	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation blocking phosphorylation signal	0.5
p.S258A	DO43017	UCEC	ICGC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation blocking phosphorylation signal	0.5
p.G192W	TCGA-EE-A3AA	SKCM	TCGA	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.0833
p.G192W	DO37571	SKCM	ICGC	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.0833
p.A191V	TCGA-ER-A19E	SKCM	TCGA	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.1111
p.A191V	DO47542	SKCM	ICGC	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.1111
p.P180T	TCGA-F5-6814	READ	TCGA	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation altering degron motif	0.7031
p.P180T	DO36556	READ	ICGC	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation altering degron motif	0.7031
p.S186N	TCGA-FI-A2D0	UCEC	TCGA	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.25
p.S186N	DO233784	GACA	ICGC	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.25
p.S186N	DO43891	UCEC	ICGC	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.25
p.S182N	TCGA-HU-8602	STAD	TCGA	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation altering degron motif	0.5958
p.S182N	DO47829	STAD	ICGC	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation altering degron motif	0.5958
p.A261G	TCGA-V5-AASW	ESCA	TCGA	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation rewiring degron network	0.1389
p.P268A	TCGA-VS-A958	CESC	TCGA	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation altering degron motif	0.7503
p.P268A	DO51639	CESC	ICGC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation altering degron motif	0.7503
p.K272T	TCGA-ZH-A8Y4	CHOL	TCGA	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation altering degron motif	0.6195
p.A277S	DO229022	LICA	ICGC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation rewiring degron network	0.25
p.A277S	DO229045	LICA	ICGC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation rewiring degron network	0.25
p.K265T	DO32831	PACA	ICGC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation blocking ubiquitination signal	0.6944
p.S186I	DO232224	PBCA	ICGC	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.25
p.G192R	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.0833
p.G192R	SW900	lung	COSMIC	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.0833
p.P174A	SIDM01608	Endometrial Carcinoma	GDSC	PVATPFSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.2778
p.P275H	SIDM01619	Endometrial Carcinoma	GDSC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation rewiring degron network	0.3056
p.P275H	ACH-000984	Endometrial/Uterine Cancer	CCLE	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation rewiring degron network	0.3056
p.V269A	ACH-001610	Brain Cancer	CCLE	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation altering degron motif	0.5825
p.K265E	ACH-001814	Bone Cancer	CCLE	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation blocking ubiquitination signal	0.6944
p.L262I	LNCaP-Clone-FGC	prostate	COSMIC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation rewiring degron network	0.1667
p.A273V	Farage	haematopoietic and lymphoid tissue	COSMIC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation altering degron motif	0.6936
p.Q266K	NB12	autonomic ganglia	COSMIC	PVTPKFT	DEG_SCF_FBW7_1	268:274	Mutation rewiring degron network	0.2778

Kaplan plot for ZYX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZYX

UniProt ID: Q15942

Entrez ID: 7791

Protein name: Zyxin (Zyxin-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZYX in