DegronMD

Uniprot ID: Q15942

Source protein: Zyxin

Source gene: ZYX

Class: DEG_SCF_FBW7_1

Location: 268:274

E3 ligase: FBXW7

DEGRON score: 0.9972

ASA_SCORE: 99.7286

COIL: 0.9599

CONS_SCORE: 0.345

DSS_SCORE: 0.5809

HELIX: 0.0121

FCONS_SCORE: 0.9855

RIG_SCORE: 0.6579

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P271H	TCGA-AG-A002	READ	TCGA	PVTPKFT	DEG_SCF_FBW7_1	0.7694
p.P268A	TCGA-VS-A958	CESC	TCGA	PVTPKFT	DEG_SCF_FBW7_1	0.7503
p.P268A	DO51639	CESC	ICGC	PVTPKFT	DEG_SCF_FBW7_1	0.7503
p.K265T	DO32831	PACA	ICGC	PVTPKFT	DEG_SCF_FBW7_1	0.6944
p.K265E	ACH-001814	Bone Cancer	CCLE	PVTPKFT	DEG_SCF_FBW7_1	0.6944
p.A273V	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PVTPKFT	DEG_SCF_FBW7_1	0.6936
p.K272T	TCGA-ZH-A8Y4	CHOL	TCGA	PVTPKFT	DEG_SCF_FBW7_1	0.6195
p.F273V	TCGA-BF-A1Q0	SKCM	TCGA	PVTPKFT	DEG_SCF_FBW7_1	0.5957
p.F273V	DO47374	SKCM	ICGC	PVTPKFT	DEG_SCF_FBW7_1	0.5957
p.V269A	ACH-001610	Brain Cancer	CCLE	PVTPKFT	DEG_SCF_FBW7_1	0.5825
p.S259Y	TCGA-2Y-A9HA	LIHC	TCGA	PVTPKFT	DEG_SCF_FBW7_1	0.5278
p.S259Y	DO219539	LIHC	ICGC	PVTPKFT	DEG_SCF_FBW7_1	0.5278
p.S258A	TCGA-D1-A17B	UCEC	TCGA	PVTPKFT	DEG_SCF_FBW7_1	0.5
p.S258A	DO43017	UCEC	ICGC	PVTPKFT	DEG_SCF_FBW7_1	0.5
p.P275H	SIDM01619	Endometrial Carcinoma	GDSC	PVTPKFT	DEG_SCF_FBW7_1	0.3056
p.P275H	ACH-000984	Endometrial/Uterine Cancer	CCLE	PVTPKFT	DEG_SCF_FBW7_1	0.3056
p.Q266K	NB12	autonomic_ganglia	COSMIC	PVTPKFT	DEG_SCF_FBW7_1	0.2778
p.A277S	DO229022	LICA	ICGC	PVTPKFT	DEG_SCF_FBW7_1	0.25
p.A277S	DO229045	LICA	ICGC	PVTPKFT	DEG_SCF_FBW7_1	0.25
p.L262I	LNCaP-Clone-FGC	prostate	COSMIC	PVTPKFT	DEG_SCF_FBW7_1	0.1667
p.A261G	TCGA-V5-AASW	ESCA	TCGA	PVTPKFT	DEG_SCF_FBW7_1	0.1389
p.P260L	TCGA-22-5473	LUSC	TCGA	PVTPKFT	DEG_SCF_FBW7_1	0.1111
p.P260L	DO26467	LUSC	ICGC	PVTPKFT	DEG_SCF_FBW7_1	0.1111
p.P260T	TCGA-AP-A051	UCEC	TCGA	PVTPKFT	DEG_SCF_FBW7_1	0.1111
p.P260T	DO42673	UCEC	ICGC	PVTPKFT	DEG_SCF_FBW7_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15942	Zyxin	DEG_SCF_FBW7_1	268:274	PVTPKFT	FBXW7	0.9972	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons