DegronMD

Uniprot ID: Q7L5A3

Source protein: Protein FAM214B

Source gene: FAM214B

Class: DEG_SCF_FBW7_1

Location: 338:345

E3 ligase: FBXW7

DEGRON score: 0.9873

ASA_SCORE: 75.6625

COIL: 0.9036

CONS_SCORE: 0.3004

DSS_SCORE: 0.5058

HELIX: 0.0521

FCONS_SCORE: 0.6753

RIG_SCORE: 0.677

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G350D	TCGA-BS-A0TA	UCEC	TCGA	PVPTPAVS	DEG_SCF_FBW7_1	0.1944
p.G350D	DO43298	UCEC	ICGC	PVPTPAVS	DEG_SCF_FBW7_1	0.1944
p.R346H	SIDM02071	Esophageal Carcinoma	GDSC	PVPTPAVS	DEG_SCF_FBW7_1	0.3056
p.P340H	SIDM02015	Colorectal Carcinoma	GDSC	PVPTPAVS	DEG_SCF_FBW7_1	0.6583
p.L349P	ACH-000900	Lung Cancer	CCLE	PVPTPAVS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L5A3	Protein FAM214B	DEG_SCF_FBW7_1	338:345	PVPTPAVS	FBXW7	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons