DegronMD - Q7L5A3(FAM214B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R308Q	TCGA-A5-A0G2	UCEC	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1667
p.R308Q	TCGA-CM-4746	COAD	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1667
p.R308Q	DO477	BLCA	ICGC	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1667
p.R308Q	DO7882	COAD	ICGC	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1667
p.R308Q	DO41235	UCEC	ICGC	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1667
p.R325Q	TCGA-B5-A0JY	UCEC	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.25
p.R325Q	TCGA-B5-A0JY	UCEC	TCGA	SPPSASPVPTP	DEG_COP1_1	332:342	Mutation rewiring degron network	0.1389
p.P320S	TCGA-B5-A3FC	UCEC	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.5641
p.G350D	TCGA-BS-A0TA	UCEC	TCGA	SPPSASPVPTP	DEG_COP1_1	332:342	Mutation rewiring degron network	0.1111
p.G350D	TCGA-BS-A0TA	UCEC	TCGA	PVPTPAVS	DEG_SCF_FBW7_1	338:345	Mutation rewiring degron network	0.1944
p.G350D	DO43298	UCEC	ICGC	SPPSASPVPTP	DEG_COP1_1	332:342	Mutation rewiring degron network	0.1111
p.G350D	DO43298	UCEC	ICGC	PVPTPAVS	DEG_SCF_FBW7_1	338:345	Mutation rewiring degron network	0.1944
p.R322Q	TCGA-EO-A22X	UCEC	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.6218
p.R322Q	TCGA-EO-A3AY	UCEC	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.6218
p.R322Q	TCGA-EO-A3B0	UCEC	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.6218
p.R322Q	DO219773	UCEC	ICGC	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.6218
p.R322Q	DO43202	UCEC	ICGC	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.6218
p.R322Q	DO43907	UCEC	ICGC	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.6218
p.R325W	TCGA-VR-AA4G	ESCA	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.25
p.R325W	TCGA-VR-AA4G	ESCA	TCGA	SPPSASPVPTP	DEG_COP1_1	332:342	Mutation rewiring degron network	0.1389
p.R346H	SIDM02071	Esophageal Carcinoma	GDSC	SPPSASPVPTP	DEG_COP1_1	332:342	Mutation rewiring degron network	0.2222
p.R346H	SIDM02071	Esophageal Carcinoma	GDSC	PVPTPAVS	DEG_SCF_FBW7_1	338:345	Mutation rewiring degron network	0.3056
p.P340H	SIDM02015	Colorectal Carcinoma	GDSC	SPPSASPVPTP	DEG_COP1_1	332:342	Mutation altering degron motif	0.7694
p.P340H	SIDM02015	Colorectal Carcinoma	GDSC	PVPTPAVS	DEG_SCF_FBW7_1	338:345	Mutation altering degron motif	0.6583
p.R315H	SIDM00217	Colorectal Carcinoma	GDSC	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.8244
p.R315H	ACH-000780	Lung Cancer	CCLE	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.8244
p.R315H	ACH-000999	Colon/Colorectal Cancer	CCLE	RRLKLSPLR	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.8244
p.P334T	SIDM00168	Head and Neck Carcinoma	GDSC	SPPSASPVPTP	DEG_COP1_1	332:342	Mutation altering degron motif	0.5919
p.P334T	ACH-000549	Head and Neck Cancer	CCLE	SPPSASPVPTP	DEG_COP1_1	332:342	Mutation altering degron motif	0.5919
p.L349P	ACH-000900	Lung Cancer	CCLE	SPPSASPVPTP	DEG_COP1_1	332:342	Mutation rewiring degron network	0.1389
p.L349P	ACH-000900	Lung Cancer	CCLE	PVPTPAVS	DEG_SCF_FBW7_1	338:345	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM214B

UniProt ID: Q7L5A3

Entrez ID: 80256

Protein name: Protein FAM214B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM214B in