DegronMD

Uniprot ID: Q7L5A3

Source protein: Protein FAM214B

Source gene: FAM214B

Class: DEG_APCC_DBOX_1

Location: 314:322

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.945

ASA_SCORE: 95.4667

COIL: 0.7603

CONS_SCORE: 0.3354

DSS_SCORE: 0.5708

HELIX: 0.1711

FCONS_SCORE: 1.0082

RIG_SCORE: 0.7356

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R308Q	TCGA-A5-A0G2	UCEC	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	0.1667
p.R308Q	TCGA-CM-4746	COAD	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	0.1667
p.R308Q	DO477	BLCA	ICGC	RRLKLSPLR	DEG_APCC_DBOX_1	0.1667
p.R308Q	DO7882	COAD	ICGC	RRLKLSPLR	DEG_APCC_DBOX_1	0.1667
p.R308Q	DO41235	UCEC	ICGC	RRLKLSPLR	DEG_APCC_DBOX_1	0.1667
p.R325Q	TCGA-B5-A0JY	UCEC	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	0.25
p.P320S	TCGA-B5-A3FC	UCEC	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	0.5641
p.R322Q	TCGA-EO-A22X	UCEC	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	0.6218
p.R322Q	TCGA-EO-A3AY	UCEC	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	0.6218
p.R322Q	TCGA-EO-A3B0	UCEC	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	0.6218
p.R322Q	DO219773	UCEC	ICGC	RRLKLSPLR	DEG_APCC_DBOX_1	0.6218
p.R322Q	DO43202	UCEC	ICGC	RRLKLSPLR	DEG_APCC_DBOX_1	0.6218
p.R322Q	DO43907	UCEC	ICGC	RRLKLSPLR	DEG_APCC_DBOX_1	0.6218
p.R325W	TCGA-VR-AA4G	ESCA	TCGA	RRLKLSPLR	DEG_APCC_DBOX_1	0.25
p.R315H	SIDM00217	Colorectal Carcinoma	GDSC	RRLKLSPLR	DEG_APCC_DBOX_1	0.8244
p.R315H	ACH-000780	Lung Cancer	CCLE	RRLKLSPLR	DEG_APCC_DBOX_1	0.8244
p.R315H	ACH-000999	Colon/Colorectal Cancer	CCLE	RRLKLSPLR	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L5A3	Protein FAM214B	DEG_APCC_DBOX_1	314:322	RRLKLSPLR	APC,CDC20,FZR1	0.945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons