DegronMD

Uniprot ID: Q7L5A3

Source protein: Protein FAM214B

Source gene: FAM214B

Class: DEG_COP1_1

Location: 332:342

E3 ligase: COP1

DEGRON score: 0.9963

ASA_SCORE: 77.5273

COIL: 0.9506

CONS_SCORE: 0.3351

DSS_SCORE: 0.5681

HELIX: 0.0223

FCONS_SCORE: 0.8458

RIG_SCORE: 0.5976

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R325Q	TCGA-B5-A0JY	UCEC	TCGA	SPPSASPVPTP	DEG_COP1_1	0.1389
p.G350D	TCGA-BS-A0TA	UCEC	TCGA	SPPSASPVPTP	DEG_COP1_1	0.1111
p.G350D	DO43298	UCEC	ICGC	SPPSASPVPTP	DEG_COP1_1	0.1111
p.R325W	TCGA-VR-AA4G	ESCA	TCGA	SPPSASPVPTP	DEG_COP1_1	0.1389
p.R346H	SIDM02071	Esophageal Carcinoma	GDSC	SPPSASPVPTP	DEG_COP1_1	0.2222
p.P340H	SIDM02015	Colorectal Carcinoma	GDSC	SPPSASPVPTP	DEG_COP1_1	0.7694
p.P334T	SIDM00168	Head and Neck Carcinoma	GDSC	SPPSASPVPTP	DEG_COP1_1	0.5919
p.P334T	ACH-000549	Head and Neck Cancer	CCLE	SPPSASPVPTP	DEG_COP1_1	0.5919
p.L349P	ACH-000900	Lung Cancer	CCLE	SPPSASPVPTP	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L5A3	Protein FAM214B	DEG_COP1_1	332:342	SPPSASPVPTP	COP1	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons