DegronMD

Uniprot ID: Q9Y6M7

Source protein: Sodium bicarbonate cotransporter 3

Source gene: SLC4A7

Class: DEG_SCF_FBW7_1

Location: 302:309

E3 ligase: FBXW7

DEGRON score: 0.9901

ASA_SCORE: 79.1625

COIL: 0.8889

CONS_SCORE: 0.1379

DSS_SCORE: 0.7749

HELIX: 0.0204

FCONS_SCORE: 1.0279

RIG_SCORE: 0.565

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P294L	TCGA-64-1679	LUAD	TCGA	PVPTPQNS	DEG_SCF_FBW7_1	0.1111
p.P304H	TCGA-D3-A8GI	SKCM	TCGA	PVPTPQNS	DEG_SCF_FBW7_1	0.6583
p.P318S	DO10880	GBM	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	0.0833
p.A304T	DO21487	LAML	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	0.7139
p.S313R	DO229027	LICA	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	0.2222
p.E316Q	DO222880	MELA	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	0.1389
p.E311K	DO38683	STAD	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	0.2778
p.E311K	DO41235	UCEC	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	0.2778
p.A304S	DO42312	UCEC	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	0.7588
p.R294G	DO41331	UCEC	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	0.1111
p.T310N	SIDM01102	Non-Cancerous	GDSC	PVPTPQNS	DEG_SCF_FBW7_1	0.3056
p.T310N	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	0.3056
p.R318H	ACH-000004	Leukemia	CCLE	PVPTPQNS	DEG_SCF_FBW7_1	0.0833
p.R318H	ACH-000005	Leukemia	CCLE	PVPTPQNS	DEG_SCF_FBW7_1	0.0833
p.R318H	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	0.0833
p.R318H	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	0.0833
p.R310H	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	0.3056
p.R310H	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	0.3056
p.R302H	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	0.8244
p.R302H	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	0.8244
p.R313P	A2780	ovary	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	0.2222
p.R314H	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	0.1944
p.R314H	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	0.1944
p.T293N	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6M7	Sodium bicarbonate cotransporter 3	DEG_SCF_FBW7_1	302:309	PVPTPQNS	FBXW7	0.9901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVPTPQNS

Degron related mutations and impact score

Drug responses associated with SLC4A7 mutations

All proteins holding degron of PVPTPQNS