DegronMD - Q9Y6M7(SLC4A7)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P294L	TCGA-64-1679	LUAD	TCGA	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.25
p.P294L	TCGA-64-1679	LUAD	TCGA	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.1111
p.R290G	TCGA-78-7150	LUAD	TCGA	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1389
p.R290T	TCGA-AC-A23H	BRCA	TCGA	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1389
p.P304H	TCGA-D3-A8GI	SKCM	TCGA	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.7694
p.P304H	TCGA-D3-A8GI	SKCM	TCGA	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.6583
p.R298G	TCGA-FI-A2D5	UCEC	TCGA	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.6457
p.I298N	DO9756	COAD	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.728
p.P318S	DO10880	GBM	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.0833
p.D291N	DO15334	HNSC	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1667
p.A304T	DO21487	LAML	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.7139
p.A304T	DO21487	LAML	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.7139
p.S313R	DO229027	LICA	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1389
p.S313R	DO229027	LICA	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.2222
p.P299T	DO229009	LICA	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.7031
p.P290L	DO26200	LUAD	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1389
p.E316Q	DO222880	MELA	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.0556
p.E316Q	DO222880	MELA	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.1389
p.P299S	DO37762	SKCM	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.6752
p.P300H	DO50284	SKCM	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.7694
p.T300M	DO51776	STAD	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.7423
p.E311K	DO38683	STAD	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1944
p.E311K	DO38683	STAD	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.2778
p.E311K	DO41235	UCEC	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1944
p.E311K	DO41235	UCEC	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.2778
p.A304S	DO42312	UCEC	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.7588
p.A304S	DO42312	UCEC	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.7588
p.R294G	DO41331	UCEC	ICGC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.25
p.R294G	DO41331	UCEC	ICGC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.1111
p.T310N	SIDM01102	Non-Cancerous	GDSC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.2222
p.T310N	SIDM01102	Non-Cancerous	GDSC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.3056
p.T310N	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.2222
p.T310N	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.3056
p.R318H	ACH-000004	Leukemia	CCLE	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.0833
p.R318H	ACH-000005	Leukemia	CCLE	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.0833
p.R318H	CMK	haematopoietic and lymphoid tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.0833
p.R318H	HEL	haematopoietic and lymphoid tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.0833
p.T301N	ACH-002316	Non-Cancerous	CCLE	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.5944
p.T301N	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.5944
p.T297N	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.7055
p.R310H	HEL	haematopoietic and lymphoid tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.2222
p.R310H	HEL	haematopoietic and lymphoid tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.3056
p.R310H	CMK	haematopoietic and lymphoid tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.2222
p.R310H	CMK	haematopoietic and lymphoid tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.3056
p.R302H	HEL	haematopoietic and lymphoid tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.8244
p.R302H	HEL	haematopoietic and lymphoid tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.8244
p.R302H	CMK	haematopoietic and lymphoid tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation altering degron motif	0.8244
p.R302H	CMK	haematopoietic and lymphoid tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.8244
p.R313P	A2780	ovary	COSMIC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1389
p.R313P	A2780	ovary	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.2222
p.R314H	CMK	haematopoietic and lymphoid tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1111
p.R314H	CMK	haematopoietic and lymphoid tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.1944
p.R314H	HEL	haematopoietic and lymphoid tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1111
p.R314H	HEL	haematopoietic and lymphoid tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.1944
p.T293N	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	297:306	Mutation rewiring degron network	0.2222
p.T293N	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	PVPTPQNS	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC4A7

UniProt ID: Q9Y6M7

Entrez ID: 9497

Protein name: Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC4A7 in