DegronMD

Uniprot ID: Q9Y6M7

Source protein: Sodium bicarbonate cotransporter 3

Source gene: SLC4A7

Class: DEG_COP1_1

Location: 297:306

E3 ligase: COP1

DEGRON score: 0.952

ASA_SCORE: 68.7

COIL: 0.7244

CONS_SCORE: 0.1301

DSS_SCORE: 0.7681

HELIX: 0.0225

FCONS_SCORE: 0.8932

RIG_SCORE: 0.6043

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P294L	TCGA-64-1679	LUAD	TCGA	SRCTTPVPTP	DEG_COP1_1	0.25
p.R290G	TCGA-78-7150	LUAD	TCGA	SRCTTPVPTP	DEG_COP1_1	0.1389
p.R290T	TCGA-AC-A23H	BRCA	TCGA	SRCTTPVPTP	DEG_COP1_1	0.1389
p.P304H	TCGA-D3-A8GI	SKCM	TCGA	SRCTTPVPTP	DEG_COP1_1	0.7694
p.R298G	TCGA-FI-A2D5	UCEC	TCGA	SRCTTPVPTP	DEG_COP1_1	0.6457
p.I298N	DO9756	COAD	ICGC	SRCTTPVPTP	DEG_COP1_1	0.728
p.D291N	DO15334	HNSC	ICGC	SRCTTPVPTP	DEG_COP1_1	0.1667
p.A304T	DO21487	LAML	ICGC	SRCTTPVPTP	DEG_COP1_1	0.7139
p.S313R	DO229027	LICA	ICGC	SRCTTPVPTP	DEG_COP1_1	0.1389
p.P299T	DO229009	LICA	ICGC	SRCTTPVPTP	DEG_COP1_1	0.7031
p.P290L	DO26200	LUAD	ICGC	SRCTTPVPTP	DEG_COP1_1	0.1389
p.E316Q	DO222880	MELA	ICGC	SRCTTPVPTP	DEG_COP1_1	0.0556
p.P299S	DO37762	SKCM	ICGC	SRCTTPVPTP	DEG_COP1_1	0.6752
p.P300H	DO50284	SKCM	ICGC	SRCTTPVPTP	DEG_COP1_1	0.7694
p.T300M	DO51776	STAD	ICGC	SRCTTPVPTP	DEG_COP1_1	0.7423
p.E311K	DO38683	STAD	ICGC	SRCTTPVPTP	DEG_COP1_1	0.1944
p.E311K	DO41235	UCEC	ICGC	SRCTTPVPTP	DEG_COP1_1	0.1944
p.A304S	DO42312	UCEC	ICGC	SRCTTPVPTP	DEG_COP1_1	0.7588
p.R294G	DO41331	UCEC	ICGC	SRCTTPVPTP	DEG_COP1_1	0.25
p.T310N	SIDM01102	Non-Cancerous	GDSC	SRCTTPVPTP	DEG_COP1_1	0.2222
p.T310N	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	0.2222
p.T301N	ACH-002316	Non-Cancerous	CCLE	SRCTTPVPTP	DEG_COP1_1	0.5944
p.T301N	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	0.5944
p.T297N	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	0.7055
p.R310H	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	0.2222
p.R310H	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	0.2222
p.R302H	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	0.8244
p.R302H	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	0.8244
p.R313P	A2780	ovary	COSMIC	SRCTTPVPTP	DEG_COP1_1	0.1389
p.R314H	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	0.1111
p.R314H	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	0.1111
p.T293N	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	SRCTTPVPTP	DEG_COP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRCTTPVPTP

Degron related mutations and impact score

Drug responses associated with SLC4A7 mutations

All proteins holding degron of SRCTTPVPTP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6M7	Sodium bicarbonate cotransporter 3	DEG_COP1_1	297:306	SRCTTPVPTP	COP1	0.952	More...