DegronMD

Uniprot ID: Q5T2E6

Source protein: Armadillo-like helical domain-containing protein 3

Source gene: ARMH3

Class: DEG_SCF_FBW7_1

Location: 337:343

E3 ligase: FBXW7

DEGRON score: 0.9473

ASA_SCORE: 76.3571

COIL: 0.9121

CONS_SCORE: 0.1865

DSS_SCORE: 0.6311

HELIX: 0.0191

FCONS_SCORE: 1.0337

RIG_SCORE: 0.6522

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T343S	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PVTPLGT	DEG_SCF_FBW7_1	0.6005
p.T343S	KYSE-180	oesophagus	COSMIC	PVTPLGT	DEG_SCF_FBW7_1	0.6005
p.P345L	SIDM01168	Colorectal Carcinoma	GDSC	PVTPLGT	DEG_SCF_FBW7_1	0.2778
p.P345L	SIDM00941	Kidney Carcinoma	GDSC	PVTPLGT	DEG_SCF_FBW7_1	0.2778
p.P345L	SIDM00382	Glioblastoma	GDSC	PVTPLGT	DEG_SCF_FBW7_1	0.2778
p.P345L	SIDM00462	Acute Myeloid Leukemia	GDSC	PVTPLGT	DEG_SCF_FBW7_1	0.2778
p.P345L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PVTPLGT	DEG_SCF_FBW7_1	0.2778
p.P345L	SIDM01517	Head and Neck Carcinoma	GDSC	PVTPLGT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T2E6	Armadillo-like helical domain-containing protein 3	DEG_SCF_FBW7_1	337:343	PVTPLGT	FBXW7	0.9473	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons