DegronMD

Uniprot ID: Q8IZS6

Source protein: Dynein light chain Tctex-type protein 2

Source gene: DYNLT2

Class: DEG_SCF_FBW7_2

Location: 24:30

E3 ligase: FBXW7

DEGRON score: 0.7927

ASA_SCORE: 118.1571

COIL: 0.8853

CONS_SCORE: 0.3183

DSS_SCORE: 0.7989

HELIX: 0.1101

FCONS_SCORE: 1.0502

RIG_SCORE: 0.6627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P27S	TCGA-BR-6452	STAD	TCGA	PVTPRKE	DEG_SCF_FBW7_2	0.6752
p.P27S	DO38404	STAD	ICGC	PVTPRKE	DEG_SCF_FBW7_2	0.6752
p.E37Q	TCGA-TS-A7OZ	MESO	TCGA	PVTPRKE	DEG_SCF_FBW7_2	0.1389
p.T26A	DO233935	GACA	ICGC	PVTPRKE	DEG_SCF_FBW7_2	0.7139
p.V25L	DO23248	LINC	ICGC	PVTPRKE	DEG_SCF_FBW7_2	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZS6	Dynein light chain Tctex-type protein 2	DEG_SCF_FBW7_2	24:30	PVTPRKE	FBXW7	0.7927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons