DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_2

Location: 4044:4050

E3 ligase: FBXW7

DEGRON score: 0.9173

ASA_SCORE: 100.3857

COIL: 0.9374

CONS_SCORE: 0.5934

DSS_SCORE: 0.6947

HELIX: 0.0126

FCONS_SCORE: 1.0459

RIG_SCORE: 0.5976

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R4053S	TCGA-49-AARE	LUAD	TCGA	PVTPSSE	DEG_SCF_FBW7_2	0.25
p.R4053S	DO218922	LUAD	ICGC	PVTPSSE	DEG_SCF_FBW7_2	0.25
p.E4050G	TCGA-98-A538	LUSC	TCGA	PVTPSSE	DEG_SCF_FBW7_2	0.7199
p.E4050G	DO219177	LUSC	ICGC	PVTPSSE	DEG_SCF_FBW7_2	0.7199
p.S4059F	TCGA-AX-A1CE	UCEC	TCGA	PVTPSSE	DEG_SCF_FBW7_2	0.0833
p.S4059F	DO42280	UCEC	ICGC	PVTPSSE	DEG_SCF_FBW7_2	0.0833
p.P4054L	TCGA-B5-A0JZ	UCEC	TCGA	PVTPSSE	DEG_SCF_FBW7_2	0.2222
p.P4054L	DO42761	UCEC	ICGC	PVTPSSE	DEG_SCF_FBW7_2	0.2222
p.P4054L	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PVTPSSE	DEG_SCF_FBW7_2	0.2222
p.P4054L	ACH-000938	Leukemia	CCLE	PVTPSSE	DEG_SCF_FBW7_2	0.2222
p.P4054L	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PVTPSSE	DEG_SCF_FBW7_2	0.2222
p.P4047S	TCGA-DS-A1OB	CESC	TCGA	PVTPSSE	DEG_SCF_FBW7_2	0.6752
p.P4047S	DO6323	CESC	ICGC	PVTPSSE	DEG_SCF_FBW7_2	0.6752
p.E4050K	TCGA-EE-A2GR	SKCM	TCGA	PVTPSSE	DEG_SCF_FBW7_2	0.7022
p.E4050K	DO222662	MELA	ICGC	PVTPSSE	DEG_SCF_FBW7_2	0.7022
p.E4050K	DO37996	SKCM	ICGC	PVTPSSE	DEG_SCF_FBW7_2	0.7022
p.R4043C	TCGA-IQ-7630	HNSC	TCGA	PVTPSSE	DEG_SCF_FBW7_2	0.3056
p.R4043C	DO14654	HNSC	ICGC	PVTPSSE	DEG_SCF_FBW7_2	0.3056
p.R4043C	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PVTPSSE	DEG_SCF_FBW7_2	0.3056
p.R4043C	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PVTPSSE	DEG_SCF_FBW7_2	0.3056
p.P4044L	TCGA-W3-AA1R	SKCM	TCGA	PVTPSSE	DEG_SCF_FBW7_2	0.6471
p.P4044L	DO51275	SKCM	ICGC	PVTPSSE	DEG_SCF_FBW7_2	0.6471
p.S4039F	DO225046	BRCA	ICGC	PVTPSSE	DEG_SCF_FBW7_2	0.1944
p.T4056A	DO233170	GACA	ICGC	PVTPSSE	DEG_SCF_FBW7_2	0.1667
p.R4043H	DO233935	GACA	ICGC	PVTPSSE	DEG_SCF_FBW7_2	0.3056
p.E4050A	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	PVTPSSE	DEG_SCF_FBW7_2	0.7701
p.E4050A	ACH-000667	Lung Cancer	CCLE	PVTPSSE	DEG_SCF_FBW7_2	0.7701
p.E4050A	HCC-44	lung	COSMIC	PVTPSSE	DEG_SCF_FBW7_2	0.7701

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTPSSE

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVTPSSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_2	4044:4050	PVTPSSE	FBXW7	0.9173	More...