DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 3228:3235

E3 ligase: FBXW7

DEGRON score: 0.9421

ASA_SCORE: 109.925

COIL: 0.9226

CONS_SCORE: 0

DSS_SCORE: 0.6235

HELIX: 0.0154

FCONS_SCORE: 0

RIG_SCORE: 0.6936

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3244Q	TCGA-50-5045	LUAD	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.0833
p.P3244Q	DO23723	LUAD	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.0833
p.I3220N	TCGA-93-8067	LUAD	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.1111
p.I3220N	DO25113	LUAD	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.1111
p.V3224A	TCGA-AA-A010	COAD	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.2222
p.S3227Y	TCGA-E6-A1M0	UCEC	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.3056
p.S3227Y	TCGA-EI-6917	READ	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.3056
p.S3227Y	TCGA-EO-A3B0	UCEC	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.3056
p.S3227Y	DO36881	READ	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.3056
p.S3227Y	DO219773	UCEC	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.3056
p.S3227Y	DO43682	UCEC	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.3056
p.P3237S	TCGA-EE-A29L	SKCM	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.2778
p.P3237S	TCGA-EE-A3AC	SKCM	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.2778
p.P3237S	DO220877	MELA	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.2778
p.P3237S	DO222599	MELA	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.2778
p.P3237S	DO37631	SKCM	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.2778
p.P3237S	DO37835	SKCM	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.2778
p.E3219D	TCGA-EO-A22R	UCEC	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.0833
p.E3219D	DO42713	UCEC	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.0833
p.T3235I	TCGA-F5-6814	READ	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.7078
p.T3235I	DO36556	READ	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.7078
p.P3228S	TCGA-FW-A3R5	SKCM	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.6752
p.P3228S	DO37406	SKCM	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.6752
p.S3227F	TCGA-GN-A266	SKCM	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.3056
p.S3227F	DO37432	SKCM	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.3056
p.T3223P	TCGA-PJ-A5Z9	KIRP	TCGA	PWKTPETT	DEG_SCF_FBW7_1	0.1944
p.T3223P	DO44504	KIRP	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.1944
p.N3226H	DO234363	ESAD	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.2778
p.R3221S	DO233751	GACA	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.1389
p.T3235N	DO229041	LICA	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.7055
p.P3237L	DO220877	MELA	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0.2778
p.ME3238IK	DO222824	MELA	ICGC	PWKTPETT	DEG_SCF_FBW7_1	0
p.N3226S	SIDM00041	Gastric Carcinoma	GDSC	PWKTPETT	DEG_SCF_FBW7_1	0.2778
p.V3224M	SIDM00660	Colorectal Carcinoma	GDSC	PWKTPETT	DEG_SCF_FBW7_1	0.2222
p.V3224M	ACH-000985	Colon/Colorectal Cancer	CCLE	PWKTPETT	DEG_SCF_FBW7_1	0.2222
p.V3224M	LS-411N	large_intestine	COSMIC	PWKTPETT	DEG_SCF_FBW7_1	0.2222
p.T3234K	SIDM00930	Osteosarcoma	GDSC	PWKTPETT	DEG_SCF_FBW7_1	0.6195
p.T3234K	ACH-001715	Bone Cancer	CCLE	PWKTPETT	DEG_SCF_FBW7_1	0.6195
p.T3234K	CAL-72	bone	COSMIC	PWKTPETT	DEG_SCF_FBW7_1	0.6195

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PWKTPETT

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PWKTPETT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	3228:3235	PWKTPETT	FBXW7	0.9421	More...