DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 10836:10840

E3 ligase: SPOP

DEGRON score: 0.7151

ASA_SCORE: 91.12

COIL: 0.7632

CONS_SCORE: 0

DSS_SCORE: 0.484

HELIX: 0.0182

FCONS_SCORE: 0

RIG_SCORE: 0.7971

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S10845G	TCGA-4Z-AA80	BLCA	TCGA	PWTTS	DEG_SPOP_SBC_1	0.1944
p.S10845G	DO218986	BLCA	ICGC	PWTTS	DEG_SPOP_SBC_1	0.1944
p.D10848E	TCGA-55-8089	LUAD	TCGA	PWTTS	DEG_SPOP_SBC_1	0.1111
p.D10848E	DO23690	LUAD	ICGC	PWTTS	DEG_SPOP_SBC_1	0.1111
p.A10829T	TCGA-A5-A0G2	UCEC	TCGA	PWTTS	DEG_SPOP_SBC_1	0.1389
p.A10829T	DO41235	UCEC	ICGC	PWTTS	DEG_SPOP_SBC_1	0.1389
p.P10833S	TCGA-AX-A05Z	UCEC	TCGA	PWTTS	DEG_SPOP_SBC_1	0.25
p.P10833S	DO40884	UCEC	ICGC	PWTTS	DEG_SPOP_SBC_1	0.25
p.S10847L	TCGA-BF-A3DL	SKCM	TCGA	PWTTS	DEG_SPOP_SBC_1	0.5833
p.S10847L	DO51238	SKCM	ICGC	PWTTS	DEG_SPOP_SBC_1	0.5833
p.P10836S	TCGA-BF-A5ES	SKCM	TCGA	PWTTS	DEG_SPOP_SBC_1	0.6752
p.P10836S	DO219456	SKCM	ICGC	PWTTS	DEG_SPOP_SBC_1	0.6752
p.F10842C	TCGA-CA-6718	COAD	TCGA	PWTTS	DEG_SPOP_SBC_1	0.2778
p.F10842C	DO7801	COAD	ICGC	PWTTS	DEG_SPOP_SBC_1	0.2778
p.H10844Y	TCGA-EE-A29C	SKCM	TCGA	PWTTS	DEG_SPOP_SBC_1	0.2222
p.H10844Y	DO222727	MELA	ICGC	PWTTS	DEG_SPOP_SBC_1	0.2222
p.H10844Y	DO38028	SKCM	ICGC	PWTTS	DEG_SPOP_SBC_1	0.2222
p.T10826M	TCGA-OR-A5J5	ACC	TCGA	PWTTS	DEG_SPOP_SBC_1	0.0556
p.T10826M	TCGA-VQ-A8P8	STAD	TCGA	PWTTS	DEG_SPOP_SBC_1	0.0556
p.T10826M	DO230323	COCA	ICGC	PWTTS	DEG_SPOP_SBC_1	0.0556
p.T10826M	DO51764	STAD	ICGC	PWTTS	DEG_SPOP_SBC_1	0.0556
p.P10828S	DO229013	COCA	ICGC	PWTTS	DEG_SPOP_SBC_1	0.1111
p.S10832I	DO50354	ESAD	ICGC	PWTTS	DEG_SPOP_SBC_1	0.2222
p.P10833T	DO229015	LICA	ICGC	PWTTS	DEG_SPOP_SBC_1	0.25
p.F10843S	DO52655	MALY	ICGC	PWTTS	DEG_SPOP_SBC_1	0.25
p.V10835A	DO222516	MELA	ICGC	PWTTS	DEG_SPOP_SBC_1	0.3056
p.P10833L	SIDM00181	Bladder Carcinoma	GDSC	PWTTS	DEG_SPOP_SBC_1	0.25
p.P10833L	SIDM01646	Non-Cancerous	GDSC	PWTTS	DEG_SPOP_SBC_1	0.25
p.P10833L	ACH-002358	Non-Cancerous	CCLE	PWTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10836:10840	PWTTS	SPOP	0.7151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PWTTS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PWTTS