DegronMD

Uniprot ID: Q9ULL0

Source protein: Acrosomal protein KIAA1210

Source gene: KIAA1210

Class: DEG_SCF_FBW7_2

Location: 1088:1095

E3 ligase: FBXW7

DEGRON score: 0.9856

ASA_SCORE: 114.95

COIL: 0.9335

CONS_SCORE: 0.4445

DSS_SCORE: 0.3977

HELIX: 0.051

FCONS_SCORE: 1.0498

RIG_SCORE: 0.7742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1078T	TCGA-50-5930	LUAD	TCGA	PWVTPKFE	DEG_SCF_FBW7_2	0.0556
p.A1078T	DO25189	LUAD	ICGC	PWVTPKFE	DEG_SCF_FBW7_2	0.0556
p.A1078T	DO229213	THCA	ICGC	PWVTPKFE	DEG_SCF_FBW7_2	0.0556
p.S1101Y	TCGA-73-4670	LUAD	TCGA	PWVTPKFE	DEG_SCF_FBW7_2	0.1667
p.S1101Y	DO25350	LUAD	ICGC	PWVTPKFE	DEG_SCF_FBW7_2	0.1667
p.A1078S	TCGA-E6-A1LX	UCEC	TCGA	PWVTPKFE	DEG_SCF_FBW7_2	0.0556
p.A1078S	DO41020	UCEC	ICGC	PWVTPKFE	DEG_SCF_FBW7_2	0.0556
p.T1091S	TCGA-FR-A2OS	SKCM	TCGA	PWVTPKFE	DEG_SCF_FBW7_2	0.7116
p.T1091S	DO37876	SKCM	ICGC	PWVTPKFE	DEG_SCF_FBW7_2	0.7116
p.S1086F	DO222710	MELA	ICGC	PWVTPKFE	DEG_SCF_FBW7_2	0.2778
p.E1095D	SIDM01228	Melanoma	GDSC	PWVTPKFE	DEG_SCF_FBW7_2	0.6758
p.E1095D	ACH-001024	Skin Cancer	CCLE	PWVTPKFE	DEG_SCF_FBW7_2	0.6758
p.E1095D	CHL-1	skin	COSMIC	PWVTPKFE	DEG_SCF_FBW7_2	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL0	Acrosomal protein KIAA1210	DEG_SCF_FBW7_2	1088:1095	PWVTPKFE	FBXW7	0.9856	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons