DegronMD

Uniprot ID: Q494U1

Source protein: Pleckstrin homology domain-containing family N member 1

Source gene: PLEKHN1

Class: DEG_SCF_FBW7_1

Location: 459:465

E3 ligase: FBXW7

DEGRON score: 0.9995

ASA_SCORE: 70.3

COIL: 0.928

CONS_SCORE: 0.4718

DSS_SCORE: 0.6196

HELIX: 0.0303

FCONS_SCORE: 1.413

RIG_SCORE: 0.6223

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T465N	TCGA-28-1760	GBM	TCGA	PYTPPAT	DEG_SCF_FBW7_1	0.7055
p.P463L	TCGA-DA-A1HY	SKCM	TCGA	PYTPPAT	DEG_SCF_FBW7_1	0.6471
p.R474W	TCGA-VQ-A924	STAD	TCGA	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	SIDM01378	Ovarian Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	SIDM00315	Glioblastoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	SIDM00687	Gastric Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	SIDM00616	Hepatocellular Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	SIDM00271	Gastric Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	SIDM00469	Pancreatic Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	SIDM01753	Gastric Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	SIDM01588	Endometrial Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	JHH-4	liver	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	KATOIII	stomach	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	MKN1	stomach	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	PSN1	pancreas	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.R474W	YKG-1	central_nervous_system	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	0.0833
p.G453E	DO219096	BLCA	ICGC	PYTPPAT	DEG_SCF_FBW7_1	0.6111
p.T455M	DO222973	BTCA	ICGC	PYTPPAT	DEG_SCF_FBW7_1	0.2222
p.T455M	DO12076	GBM	ICGC	PYTPPAT	DEG_SCF_FBW7_1	0.2222
p.R455C	DO227549	COCA	ICGC	PYTPPAT	DEG_SCF_FBW7_1	0.2222
p.R468H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.25
p.R468H	SIDM01146	Gastric Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.25
p.R468H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	0.25
p.R468H	NCI-SNU-1	stomach	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	0.25
p.R468C	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.25
p.R468C	SK-LU-1	lung	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	0.25
p.D458N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.3056
p.D458N	ACH-001127	Leukemia	CCLE	PYTPPAT	DEG_SCF_FBW7_1	0.3056
p.D458N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	0.3056
p.D472N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PYTPPAT	DEG_SCF_FBW7_1	0.1389
p.D472N	ACH-001127	Leukemia	CCLE	PYTPPAT	DEG_SCF_FBW7_1	0.1389
p.D472N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	0.1389
p.E449K	HPAF-II	pancreas	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PYTPPAT

Degron related mutations and impact score

Drug responses associated with PLEKHN1 mutations

All proteins holding degron of PYTPPAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q494U1	Pleckstrin homology domain-containing family N member 1	DEG_SCF_FBW7_1	459:465	PYTPPAT	FBXW7	0.9995	More...