DegronMD - Q494U1(PLEKHN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T465N	TCGA-28-1760	GBM	TCGA	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation altering degron motif	0.7055
p.P463L	TCGA-DA-A1HY	SKCM	TCGA	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation altering degron motif	0.6471
p.G219D	TCGA-G4-6588	COAD	TCGA	SRVKLQHLP	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1389
p.G219D	DO10140	COAD	ICGC	SRVKLQHLP	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1389
p.R474W	TCGA-VQ-A924	STAD	TCGA	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	SIDM01378	Ovarian Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	SIDM00315	Glioblastoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	SIDM00687	Gastric Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	SIDM00616	Hepatocellular Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	SIDM00271	Gastric Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	SIDM00469	Pancreatic Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	SIDM01753	Gastric Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	SIDM01588	Endometrial Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	JHH-4	liver	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	KATOIII	stomach	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	MKN1	stomach	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	PSN1	pancreas	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.R474W	YKG-1	central nervous system	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0833
p.G453E	DO219096	BLCA	ICGC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation blocking phosphorylation signal	0.6111
p.T455M	DO222973	BTCA	ICGC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.2222
p.T455M	DO12076	GBM	ICGC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.2222
p.R455C	DO227549	COCA	ICGC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.2222
p.R223Q	DO233872	GACA	ICGC	SRVKLQHLP	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.25
p.R223Q	DO22219	LGG	ICGC	SRVKLQHLP	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.25
p.R223Q	HuO-3N1	bone	COSMIC	SRVKLQHLP	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.25
p.R468H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.25
p.R468H	SIDM01146	Gastric Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.25
p.R468H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.25
p.R468H	NCI-SNU-1	stomach	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.25
p.R468C	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.25
p.R468C	SK-LU-1	lung	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.25
p.Q238R	SIDM00683	Prostate Carcinoma	GDSC	SRVKLQHLP	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.2222
p.D458N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.3056
p.D458N	ACH-001127	Leukemia	CCLE	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.3056
p.D458N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.3056
p.D472N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.1389
p.D472N	ACH-001127	Leukemia	CCLE	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.1389
p.D472N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.1389
p.G234V	ACH-000427	Gastric Cancer	CCLE	SRVKLQHLP	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.7532
p.R241W	ACH-001382	Pancreatic Cancer	CCLE	SRVKLQHLP	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1389
p.P218L	ACH-001591	Lung Cancer	CCLE	SRVKLQHLP	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1111
p.Y223C	MRK-nu-1	breast	COSMIC	SRVKLQHLP	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.25
p.E449K	HPAF-II	pancreas	COSMIC	PYTPPAT	DEG_SCF_FBW7_1	459:465	Mutation rewiring degron network	0.0556

Kaplan plot for PLEKHN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHN1

UniProt ID: Q494U1

Entrez ID: 84069

Protein name: Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHN1 in