DegronMD

Uniprot ID: Q494U1

Source protein: Pleckstrin homology domain-containing family N member 1

Source gene: PLEKHN1

Class: DEG_APCC_DBOX_1

Location: 226:234

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6704

ASA_SCORE: 51.7444

COIL: 0.3971

CONS_SCORE: 0.6117

DSS_SCORE: 0.2865

HELIX: 0.0349

FCONS_SCORE: 1.1831

RIG_SCORE: 0.7884

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G234V	ACH-000427	Gastric Cancer	CCLE	SRVKLQHLP	DEG_APCC_DBOX_1	0.7532
p.R223Q	DO233872	GACA	ICGC	SRVKLQHLP	DEG_APCC_DBOX_1	0.25
p.R223Q	DO22219	LGG	ICGC	SRVKLQHLP	DEG_APCC_DBOX_1	0.25
p.R223Q	HuO-3N1	bone	COSMIC	SRVKLQHLP	DEG_APCC_DBOX_1	0.25
p.Y223C	MRK-nu-1	breast	COSMIC	SRVKLQHLP	DEG_APCC_DBOX_1	0.25
p.Q238R	SIDM00683	Prostate Carcinoma	GDSC	SRVKLQHLP	DEG_APCC_DBOX_1	0.2222
p.G219D	TCGA-G4-6588	COAD	TCGA	SRVKLQHLP	DEG_APCC_DBOX_1	0.1389
p.G219D	DO10140	COAD	ICGC	SRVKLQHLP	DEG_APCC_DBOX_1	0.1389
p.R241W	ACH-001382	Pancreatic Cancer	CCLE	SRVKLQHLP	DEG_APCC_DBOX_1	0.1389
p.P218L	ACH-001591	Lung Cancer	CCLE	SRVKLQHLP	DEG_APCC_DBOX_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q494U1	Pleckstrin homology domain-containing family N member 1	DEG_APCC_DBOX_1	226:234	SRVKLQHLP	APC,CDC20,FZR1	0.6704	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons