DegronMD

Uniprot ID: O43776

Source protein: Asparagine--tRNA ligase, cytoplasmic

Source gene: NARS1

Class: DEG_APCC_KENBOX_2

Location: 49:53

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6813

ASA_SCORE: 108.84

COIL: 0.7496

CONS_SCORE: 0.336

DSS_SCORE: 0.3458

HELIX: 0.1862

FCONS_SCORE: 0.9356

RIG_SCORE: 0.7831

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I44V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	QKENE	DEG_APCC_KENBOX_2	0.1944
p.E53K	SIDM01064	Hodgkin's Lymphoma	GDSC	QKENE	DEG_APCC_KENBOX_2	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43776	Asparagine--tRNA ligase, cytoplasmic	DEG_APCC_KENBOX_2	49:53	QKENE	APC,CDC20,FZR1	0.6813	More...
Q86Y56	Dynein axonemal assembly factor 5	DEG_APCC_KENBOX_2	317:321	QKENE	APC,CDC20,FZR1	0.6928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons