DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
QKENE
Uniprot ID:
Q86Y56
Source protein:
Dynein axonemal assembly factor 5
Source gene:
DNAAF5
Class:
DEG_APCC_KENBOX_2
Location:
317:321
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6928
ASA_SCORE:
93.9
COIL:
0.4858
CONS_SCORE:
0.5534
DSS_SCORE:
0.4292
HELIX:
0.5036
FCONS_SCORE:
1.2025
RIG_SCORE:
0.743
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.W316R
SIDM00333
Endometrial Carcinoma
GDSC
QKENE
DEG_APCC_KENBOX_2
0.3056
p.L308F
SIDM01100
Neuroblastoma
GDSC
QKENE
DEG_APCC_KENBOX_2
0.0833
Drug responses associated with DNAAF5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QKENE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43776
Asparagine--tRNA ligase, cytoplasmic
DEG_APCC_KENBOX_2
49:53
QKENE
APC,CDC20,FZR1
0.6813
More...
Q86Y56
Dynein axonemal assembly factor 5
DEG_APCC_KENBOX_2
317:321
QKENE
APC,CDC20,FZR1
0.6928
More...