DegronMD

Uniprot ID: Q99814

Source protein: Endothelial PAS domain-containing protein 1

Source gene: EPAS1

Class: DEG_SIAH_1

Location: 572:580

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.8175

ASA_SCORE: 88.2889

COIL: 0.9419

CONS_SCORE: 0.767

DSS_SCORE: 0.3198

HELIX: 0.0259

FCONS_SCORE: 1.084

RIG_SCORE: 0.716

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P579T	TCGA-VQ-AA69	STAD	TCGA	QPLAPVAPH	DEG_SIAH_1	0.7031
p.P579T	DO222385	STAD	ICGC	QPLAPVAPH	DEG_SIAH_1	0.7031
p.F564L	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	QPLAPVAPH	DEG_SIAH_1	0.1111
p.F564L	ACH-000309	Lung Cancer	CCLE	QPLAPVAPH	DEG_SIAH_1	0.1111
p.F564L	SK-LU-1	lung	COSMIC	QPLAPVAPH	DEG_SIAH_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99814	Endothelial PAS domain-containing protein 1	DEG_SIAH_1	572:580	QPLAPVAPH	SIAH1,SIAH2,SIAH3	0.8175	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons