DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
QRDSLAAMA
Uniprot ID:
H7BZ55
Source protein:
Ciliary rootlet coiled-coil protein 2
Source gene:
CROCC2
Class:
DEG_APCC_DBOX_1
Location:
619:627
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5673
ASA_SCORE:
93.9444
COIL:
0.0188
CONS_SCORE:
0.5857
DSS_SCORE:
0.2855
HELIX:
0.9819
FCONS_SCORE:
1.163
RIG_SCORE:
0.7906
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S622Y
SIDM01184
Bladder Carcinoma
GDSC
QRDSLAAMA
DEG_APCC_DBOX_1
0.6009
Drug responses associated with CROCC2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QRDSLAAMA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
H7BZ55
Ciliary rootlet coiled-coil protein 2
DEG_APCC_DBOX_1
619:627
QRDSLAAMA
APC,CDC20,FZR1
0.5673
More...