DegronMD

Uniprot ID: O00292

Source protein: Left-right determination factor 2

Source gene: LEFTY2

Class: DEG_APCC_DBOX_1

Location: 204:212

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8315

ASA_SCORE: 78.3111

COIL: 0.7124

CONS_SCORE: 0.5103

DSS_SCORE: 0.2699

HELIX: 0.1618

FCONS_SCORE: 0.9164

RIG_SCORE: 0.7075

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q200H	TCGA-DU-A7T6	LGG	TCGA	QREHLGPLA	DEG_APCC_DBOX_1	0.2222
p.Q200H	DO51814	LGG	ICGC	QREHLGPLA	DEG_APCC_DBOX_1	0.2222
p.Q200H	SIDM00009	Acute Myeloid Leukemia	GDSC	QREHLGPLA	DEG_APCC_DBOX_1	0.2222
p.Q200H	ACH-002390	Leukemia	CCLE	QREHLGPLA	DEG_APCC_DBOX_1	0.2222
p.Q200H	MC-1010	haematopoietic_and_lymphoid_tissue	COSMIC	QREHLGPLA	DEG_APCC_DBOX_1	0.2222
p.R205M	TCGA-G4-6628	COAD	TCGA	QREHLGPLA	DEG_APCC_DBOX_1	0.8632
p.R205M	DO10132	COAD	ICGC	QREHLGPLA	DEG_APCC_DBOX_1	0.8632
p.H216Q	DO229026	LICA	ICGC	QREHLGPLA	DEG_APCC_DBOX_1	0.2222
p.A212V	DO220901	MELA	ICGC	QREHLGPLA	DEG_APCC_DBOX_1	0.5825
p.R220H	SIDM02039	Colorectal Carcinoma	GDSC	QREHLGPLA	DEG_APCC_DBOX_1	0.1111
p.Q195H	SIDM00217	Colorectal Carcinoma	GDSC	QREHLGPLA	DEG_APCC_DBOX_1	0.0833
p.Q195H	ACH-000999	Colon/Colorectal Cancer	CCLE	QREHLGPLA	DEG_APCC_DBOX_1	0.0833
p.A215T	SIDM01609	Endometrial Carcinoma	GDSC	QREHLGPLA	DEG_APCC_DBOX_1	0.25
p.A215T	ACH-000972	Endometrial/Uterine Cancer	CCLE	QREHLGPLA	DEG_APCC_DBOX_1	0.25
p.R220C	ACH-001786	Colon/Colorectal Cancer	CCLE	QREHLGPLA	DEG_APCC_DBOX_1	0.1111
p.P219R	NCI-H23	lung	COSMIC	QREHLGPLA	DEG_APCC_DBOX_1	0.1389
p.L196F	SU-DHL-8	NS	COSMIC	QREHLGPLA	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00292	Left-right determination factor 2	DEG_APCC_DBOX_1	204:212	QREHLGPLA	APC,CDC20,FZR1	0.8315	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons