DegronMD - O00292(LEFTY2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W281C	TCGA-99-7458	LUAD	TCGA	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.0556
p.W281C	DO25416	LUAD	ICGC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.0556
p.C264R	TCGA-BG-A0M4	UCEC	TCGA	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.3056
p.C264R	TCGA-D7-A6EY	STAD	TCGA	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.3056
p.C264R	DO50118	STAD	ICGC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.3056
p.C264R	DO41686	UCEC	ICGC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.3056
p.Q200H	TCGA-DU-A7T6	LGG	TCGA	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.2222
p.Q200H	DO51814	LGG	ICGC	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.2222
p.Q200H	SIDM00009	Acute Myeloid Leukemia	GDSC	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.2222
p.Q200H	ACH-002390	Leukemia	CCLE	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.2222
p.Q200H	MC-1010	haematopoietic and lymphoid tissue	COSMIC	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.2222
p.R205M	TCGA-G4-6628	COAD	TCGA	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.8632
p.R205M	DO10132	COAD	ICGC	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.8632
p.R265H	DO222765	COCA	ICGC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation altering degron motif	0.8244
p.D271E	DO229029	LICA	ICGC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation altering degron motif	0.5647
p.H216Q	DO229026	LICA	ICGC	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.2222
p.A212V	DO220901	MELA	ICGC	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.5825
p.R262H	DO42673	UCEC	ICGC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.25
p.R220H	SIDM02039	Colorectal Carcinoma	GDSC	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.1111
p.D271V	SIDM00537	Colorectal Carcinoma	GDSC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation altering degron motif	0.7785
p.D271V	ACH-000982	Colon/Colorectal Cancer	CCLE	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation altering degron motif	0.7785
p.D271V	ACH-001345	Colon/Colorectal Cancer	CCLE	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation altering degron motif	0.7785
p.D271V	GP5d	large intestine	COSMIC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation altering degron motif	0.7785
p.Q195H	SIDM00217	Colorectal Carcinoma	GDSC	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.0833
p.Q195H	ACH-000999	Colon/Colorectal Cancer	CCLE	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.0833
p.M257T	SIDM00901	Endometrial Carcinoma	GDSC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.1111
p.M257T	ACH-000940	Endometrial/Uterine Cancer	CCLE	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.1111
p.M257T	AN3-CA	endometrium	COSMIC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.1111
p.M275T	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.2222
p.M275T	ACH-001498	Lymphoma	CCLE	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.2222
p.M275T	Farage	haematopoietic and lymphoid tissue	COSMIC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.2222
p.A215T	SIDM01609	Endometrial Carcinoma	GDSC	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.25
p.A215T	ACH-000972	Endometrial/Uterine Cancer	CCLE	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.25
p.E259D	ACH-000662	Lung Cancer	CCLE	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.1667
p.E259K	ACH-000928	Endometrial/Uterine Cancer	CCLE	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation rewiring degron network	0.1667
p.R220C	ACH-001786	Colon/Colorectal Cancer	CCLE	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.1111
p.A269V	DG-75	haematopoietic and lymphoid tissue	COSMIC	RQEMYID	LIG_APCC_ABBAyCdc20_2	265:271	Mutation altering degron motif	0.6936
p.P219R	NCI-H23	lung	COSMIC	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.1389
p.L196F	SU-DHL-8	NS	COSMIC	QREHLGPLA	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LEFTY2

UniProt ID: O00292

Entrez ID: 7044

Protein name: Left-right determination factor 2 (Endometrial bleeding-associated factor) (Left-right determination factor A) (Protein lefty-2) (Protein lefty-A) (Transforming growth factor beta-4) (TGF-beta-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LEFTY2 in