DegronMD

Uniprot ID: O00292

Source protein: Left-right determination factor 2

Source gene: LEFTY2

Class: LIG_APCC_ABBAyCdc20_2

Location: 265:271

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5722

ASA_SCORE: 70.4143

COIL: 0.3017

CONS_SCORE: 0.6405

DSS_SCORE: 0.1945

HELIX: 0.035

FCONS_SCORE: 1.1586

RIG_SCORE: 0.9138

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W281C	TCGA-99-7458	LUAD	TCGA	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.0556
p.W281C	DO25416	LUAD	ICGC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.0556
p.C264R	TCGA-BG-A0M4	UCEC	TCGA	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.3056
p.C264R	TCGA-D7-A6EY	STAD	TCGA	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.3056
p.C264R	DO50118	STAD	ICGC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.3056
p.C264R	DO41686	UCEC	ICGC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.3056
p.R265H	DO222765	COCA	ICGC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.8244
p.D271E	DO229029	LICA	ICGC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.5647
p.R262H	DO42673	UCEC	ICGC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.25
p.D271V	SIDM00537	Colorectal Carcinoma	GDSC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.7785
p.D271V	ACH-000982	Colon/Colorectal Cancer	CCLE	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.7785
p.D271V	ACH-001345	Colon/Colorectal Cancer	CCLE	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.7785
p.D271V	GP5d	large_intestine	COSMIC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.7785
p.M257T	SIDM00901	Endometrial Carcinoma	GDSC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.1111
p.M257T	ACH-000940	Endometrial/Uterine Cancer	CCLE	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.1111
p.M257T	AN3-CA	endometrium	COSMIC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.1111
p.M275T	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.2222
p.M275T	ACH-001498	Lymphoma	CCLE	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.2222
p.M275T	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.2222
p.E259D	ACH-000662	Lung Cancer	CCLE	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.1667
p.E259K	ACH-000928	Endometrial/Uterine Cancer	CCLE	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.1667
p.A269V	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	RQEMYID	LIG_APCC_ABBAyCdc20_2	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00292	Left-right determination factor 2	LIG_APCC_ABBAyCdc20_2	265:271	RQEMYID	APC,CDC20,FZR1	0.5722	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RQEMYID

Degron related mutations and impact score

Drug responses associated with LEFTY2 mutations

All proteins holding degron of RQEMYID